Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?
Leuven, Belgium. The goal of this discussion is to explore the implications of two recent papers, which
Upcoming Webinars
No Upcoming Webinars AvailableALL WEBINARS
117 RESULTS
You searched papers/autophagy-failure-alzheimers-disease-locating-primary-defect
Sort By:
- Most Recent
- Most Commented
- Most Relevant
Presenilin Loss of Function—Plan B for AD?
a lively Alzforum discussion when Peter Davies initiated a conversation about a paper from Bart de
Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis
We invite you to participate in this "offline" Forum discussion led by Vincent Marchesi of Yale University. Coming from a different research field, Marchesi has in recent years followed the AD literature as closely as have few other outside obse
Herpes Simplex and Alzheimer’s—Time to Think Again?
On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared som
Cell Death: Time to Push It Out of the Doldrums
We invite you to participate in this Forum Discussion with Yong Shen (Sun Health Research Institute). This discussion will not be hosted via our live discussion software. Instead, we will develop written exchanges between our participants and Yong Shen. T
Reimagining Alzheimer's Disease—Time for Bright New Ideas?
Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger
Calcium Signaling Deficit in the Origin of Alzheimer's Disease
Live discussion and panel of participants scheduled for 7 September 2001. Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe
Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore?
proteopathies. Trends Neurosci. 2006 Aug;29(8):438-43. Abstract Selected Primary Papers on Seeding: Bolmont T,
β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease
thanks.. I was just looking at an older Selkoe paper concluding IDE mostly works extracellularly. Gabrielle
The Cell Cycle and Alzheimer’s Disease—Let's Unite for Division!
die but without forming NFT. (paper under review). Craig Atwood: Inez, for amyloid in Niemann-Pick
The AD8—Dementia Screen Ready for Prime Time?
Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against neuropsy
Calcium in AD Pathogenesis
yes, Cell Calcium paper from De Smedt's group (see Kasri et al., 2006). Please see detailed
In Search of γ-Secretase
panelists with a remark? Otherwise, we'll go on.... Hardy: COMMENT The Nature paper reported
Nomenclature Discussion
pre-medline is out! June: I can live with that. Colin Masters: Just review the last hundred papers. Msmith:
Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and Neurotoxicity in Alzheimer's Disease
gonadotrophin levels under any circumstances. A paper on ovariectomy effects on Ab load in transgenic mice is in
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
Current Filters
- Keyword: papers/autophagy-failure-alzheimers-disease-locating-primary-defect x