Stefan Lichtenthaler on Follow the Leader to Higher BACE Levels

COMMENT As mentioned above in the comment posted by Martin Citron (March 18, 2004), we have a paper in

Takaomi Saido on Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.

COMMENT It would be interesting to see the effect of aging on the relative stoichiometry of APP, alcadein, FE65, etc. (and and their interactions). 0 saido

Takaomi Saido on Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.

COMMENT It would be very interesting to examine what happens to entorhinal cortex, where initial neurodegeneration takes place in humans. 0 saido

Bart De Strooper on The Senility-Presenilin Connection Turned Upside Down

COMMENT I am quite impressed by this paper, which dives very deep and is of high quality. The observations raise two important issues: 1. Given the apparent central role of the presenilins in memory, and given the fact that loss of presenilins causes neurodegener

George Bartzokis on Wrap it Up! Neuregulin Directs Axonal Myelination

COMMENT Being human and the myelin on small fibers: Implications for the dementias and multiple other neuropsychiatric disorders By examining mice, Michailov et al. (2004) might have given us an important lead about the mechanisms that make our brain (and the dis

Yaakov Stern on Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI.

COMMENT This article makes the very interesting observation that the “default-mode” network differs in healthy elders and patients with Alzheimer’s disease. It contributes to our understanding of the commonly observed changes in resting cerebral metabolism in Alz

Neil Hartman on Smoking Debate Still Smolders

COMMENT The problem with testing smokers and ex-smokers to determine if nicotine has neuroprotective properties is obvious. This is an unhealthy route of entry for nicotine, as opposed to transdermal, gum, lozenge, etc., where the cerebral vascular, oncologic, an

Kelly Dineley on Smoking Debate Still Smolders

COMMENT Nicotine as a pure drug has been demonstrated to be neuroprotective in numerous in-vivo and in-vitro models. In-vitro studies indicate that the α7 subtype of nAChR mediates some types of nicotine-induced neuroprotection in cortical and hippocampal neuron

Thomas Beach on Smoking Debate Still Smolders

COMMENT The epidemiological evidence should now be regarded as strongly against a protective role for smoking in Alzheimer's disease. Although several early prevalence studies showed that AD was less prevalent in elderly smokers, at least one large incidence

Takaomi Saido on Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.

COMMENT The approaches taken by the authors seem sound and the findings are interesting and suggestive. Synthesis of a solely calpain-specific low molecular weight inhibitor may lead to a "dream medication" that can be used to treat Alzheimer's dis

Takaomi Saido on Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry.

COMMENT The approach described in this work may prove to be a very effective tool for identifying target molecules involved in the pathological cascade, particularly neuronal dysfunction, of Alzheimer's disease. 0 saido

Gabriel Corfas on Wrap it Up! Neuregulin Directs Axonal Myelination

COMMENT Comment by Gabriel Corfas, Kristine Roy, and Suzhen Chen Over the last decade, evidence

Benjamin Wolozin on Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins.

COMMENT This interesting article by Hoglund and colleagues shows that statins do not lower plasma Aβ levels in patients treated with statins. The work is well-designed and well-controlled. The investigators studied two different statins, simvastatin and atorvasta

Randy Buckner on Network Diagnostics: "Default-Mode" Brain Areas Identify Early AD

COMMENT Comment by Randy L. Buckner and Cindy Lustig A major challenge to developing therapies for

Andre Delacourte on The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

COMMENT Important paper that dissects a pathway of APP signalling possibly involved in the etiopathogenesis of AD. 0 andre.delacourte