Rachelle Doody on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT designed to show that donepezil is not worth the cost. Many people have commented on the methodological

A. Nonymous on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT It's sad that pharma's hype about Alzheimer drugs leads families that cannot afford these top shelf drugs to feel so guilty. Patients know that a drug exists for their loved one and believe it would be negligent to withhold it. The industry prey

Robert Peers on Huntingtin, BDNF, Neurodegeneration: Is Speed of the Essence?

COMMENT Cortisol, I believe, inhibits BDNF expression or function. Fatty diet (low in Essential Fatty Acids-EFA) causes permanent stress in the offspring—with raised cortisol and homocysteine—when consumed in pregnancy. Fatty adult diet causes mitochondrial uncou

Michael R D'Andrea on The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination.

COMMENT a known marker of oligodendrocytes. Although this study did not comment on the BBB, one must concede that

Sam Gandy on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT Alzheimer drug Aricept” (June 25, 2004). The New York Times. Official comment from the Alzheimer’s

Ming Chen on After 40, DNA Damage Accrues in Genes, Hampering Expression

COMMENT Yankner and his colleagues have done an excellent job of showing that aging is a cause of cognitive decline. Although this has been thought for a long time, it has not been directly supported until very recently with the latest technology. The study shows

Michael Leski on Promoter Bashing—Mitochondrial Ones Damaged in AD Brain

COMMENT This is a remarkable paper. Coskun, Beal and Wallace demonstrate that many mutations to mtDNA occur near the PL region, an important regulatory region for replication of the genome. Therefore, this damage could ultimately block mitochondrial reproduction.

Laura Fisher on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT I thought Aricept gave my father a painful bilateral arthritic reaction of both hands and both feet, which led to his being treated briefly with steroids (which, incidentally, brought a discernible temporary improvement in his mentation) and at length wit

Malka Cohen-Armon on Learning from Molluscs—PolyADP-Ribosylation and Memory

COMMENT The credit should also be shared with my colleagues at Bar-Ilan University, Israel, who helped me in testing my hypothesis that PARP has a role in memory formation, which evolved from my JCB paper mentioned above (Homburg et al., 2000). Dr. M. Cohen-Armon

Pierre Tariot on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT My simplified view is that the study was unable to answer the main questions that it posed, so it is largely uninformative with respect to effectiveness outcomes. That having been said, the study at least suggests that the effectiveness of these agents is

Kevin Roth on Cell Death: Time to Push It Out of the Doldrums

COMMENT Coleman's comments, who argues, and I concur, that the critical event in AD pathogenesis is synaptic

Tori Watson on Could Alzheimer’s Drugs Mean “Good Night” to Good Memory?

COMMENT I found your article interesting. I am not a reseacher, but my father has AD, and he tells me that Aricept makes him dream vividly throughout the night. I also worked in a sleep clinic for a number of years, and we were told by our supervisors that it was

David Geldmacher on Cholinesterase Inhibitors Not What They're Cracked Up To Be?

COMMENT David S. Geldmacher, MD “AD2000” is a long-term, double-blind, placebo-controlled study of donepezil in patients with Alzheimer’s disease. In the results published in the Lancet paper, the authors found that donepezil treatment resulted in higher cognitiv

Li-Huei Tsai on Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemia.

COMMENT A previous study from Dr. YouMing Lu and colleagues reported that Cdk5 activation after ischemia leads to activation of the NMDA receptor via Ser1232 phosphorylation of NR2A (Wang et al., 2003). The authors further demonstrated that calpain activation and

Stephen D. Ginsberg on GLOing Reports from Gene Profiling of Mouse Models

COMMENT In the provocative report by Chen et al., oligonucleotide array analysis was performed using whole brain from P301L-transgenic mice as an input source of RNA. P301L mice express the longest human brain tau isoform, i.e., "big tau," with a pathog