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COMMENT In this paper, the authors conducted an interesting secondary analysis of CSF and longitudinal tau PET data from ADNI. CSF levels of GAP-43, a presynaptic protein important in neurodevelopment and in axonal regeneration, are increased in MCI and AD, and h
COMMENT The take-home message from this research article is that in AD, synaptic changes, manifested by increased levels of the presynaptic protein GAP-43, are closely associated with the accelerated spread of tau pathology. The study found that higher levels of
COMMENT The recent article by Franzmeier et al. demonstrated, with a series of very elegant analyses, that the synaptic biomarker GAP-43 associates with the spreading and accumulation of Aβ-related tau pathology. The study somewhat challenges the perhaps more “tr
PAPER Wang YT, Ashton NJ, Servaes S, Nilsson J, Woo MS, Pascoal TA, Tissot C, Rahmouni N, Therriault J, Lussier F, Chamoun M, Gauthier S, Brinkmalm A, Zetterberg H, Blennow K, Rosa-Neto P, Benedet AL
RESEARCH NEWS 2024-01-17 Research News Some scientists believe that toxic tau fibrils hop between synapses to spread throughout the brain, prompted by Aβ aggregates and overactive neurons. New imaging and biomarker data add weight to this theory. In the January 3 Nature Communica
Other Q: Why is this paper, which was just published, not in the database? A: There is usually a delay between when a paper is published online and when it is entered in PubMed. See also our selection criteria in the Methods page. Q: Can I get the full text of
Other The PubMed database is searched nightly, using a broad range of terms as keyword searches. Alzforum curators screen the abstracts and select papers based on their perceived interest to Alzheimer’s disease researchers. All papers directly related to Alzhei
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