Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K. The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. J Biol Chem. 2004 Apr 30;279(18):18146-56. PubMed.

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- Takaomi Saido
  RIKEN Center for Brain Science
- Posted: 01 Mar 2004
This work makes the epsilon cleavage of APP more important in understanding the mechanism of gamma-secretase action. It would be interesting to know whether FAD mutations in presenilin influence epsilon cleavage of APP and APLPs.

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