Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42. J Biol Chem. 1998 Aug 14;273(33):21153-60. PubMed.
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Osaka City University Medical School
It is challengeable and interesting that dimeric formation may be coupled with truncation of PS2.
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