Tiraboschi P, Hansen LA, Thal LJ, Corey-Bloom J.
The importance of neuritic plaques and tangles to the development and evolution of AD.
Neurology. 2004 Jun 8;62(11):1984-9.
PubMed.
When do the "earliest symptoms of Alzheimer's disease" become apparent? Evidence is mounting that cognitive deficits can be uncovered well in advance of the clinical diagnosis of AD (e.g., Kawas et al., 2003, Kawas, 2003).
Similarly, we now know that peptides of APP and alterations in tau can be detected in the absence of any traditional plaque form or frank NFT. It is time that we move beyond the neuropathological stigmata of AD described by Alois Alzheimer over 100 years ago to explore alternate molecular, biochemical functional and structural aspects of tis disease.
References:
Kalita CC, Kerman JD, Strecker HJ.
Preparation and properties of ornithine-oxo-acid aminotransferase of rat kidney. Comparison with the liver enzyme.
Biochim Biophys Acta. 1976 May 13;429(3):780-97.
PubMed.
Kawas CH.
Clinical practice. Early Alzheimer's disease.
N Engl J Med. 2003 Sep 11;349(11):1056-63.
PubMed.
Comments
Banner Research Institute
When do the "earliest symptoms of Alzheimer's disease" become apparent? Evidence is mounting that cognitive deficits can be uncovered well in advance of the clinical diagnosis of AD (e.g., Kawas et al., 2003, Kawas, 2003).
Similarly, we now know that peptides of APP and alterations in tau can be detected in the absence of any traditional plaque form or frank NFT. It is time that we move beyond the neuropathological stigmata of AD described by Alois Alzheimer over 100 years ago to explore alternate molecular, biochemical functional and structural aspects of tis disease.
References:
Kalita CC, Kerman JD, Strecker HJ. Preparation and properties of ornithine-oxo-acid aminotransferase of rat kidney. Comparison with the liver enzyme. Biochim Biophys Acta. 1976 May 13;429(3):780-97. PubMed.
Kawas CH. Clinical practice. Early Alzheimer's disease. N Engl J Med. 2003 Sep 11;349(11):1056-63. PubMed.
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