Sniekers S, Stringer S, Watanabe K, Jansen PR, Coleman JR, Krapohl E, Taskesen E, Hammerschlag AR, Okbay A, Zabaneh D, Amin N, Breen G, Cesarini D, Chabris CF, Iacono WG, Ikram MA, Johannesson M, Koellinger P, Lee JJ, Magnusson PK, McGue M, Miller MB, Ollier WE, Payton A, Pendleton N, Plomin R, Rietveld CA, Tiemeier H, van Duijn CM, Posthuma D. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat Genet. 2017 Jul;49(7):1107-1112. Epub 2017 May 22 PubMed.
Recommends
Please login to recommend the paper.
Comments
University of Toronto
The investigation of genetic architecture of intelligence in such a large European data set is a very exciting topic. It is intriguing that among other significant findings, two loci (EXOC4 and MEF2C) were previously associated with Alzheimer’s disease. It would be important to see if some of the findings are replicated in the different ethnic groups. This is of note, because in our study of long runs of homozygosity in a Caribbean Hispanic cohort, a consensus region at the EXOC4 locus was significantly associated with Alzheimer’s disease (Ghani et al., 2013). EXOC4-intersecting runs of homozygosity might harbor variations influencing both risk for Alzheimer’s disease and intelligence.
References:
Ghani M, Sato C, Lee JH, Reitz C, Moreno D, Mayeux R, St George-Hyslop P, Rogaeva E. Evidence of Recessive Alzheimer Disease Loci in a Caribbean Hispanic Data Set: Genome-wide Survey of Runs of Homozygosity. JAMA Neurol. 2013 Aug 26; PubMed.
View all comments by Ekaterina RogaevaMake a Comment
To make a comment you must login or register.