Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, Reisz JA, Prag HA, Garcia-Segura ME, Wu V, Xiang Y, Barlas B, Casey AM, van den Bosch AM, Nicaise AM, Roth L, Bates GR, Huang H, Prasad P, Vincent AE, Frezza C, Viscomi C, Balmus G, Takats Z, Marioni JC, D'Alessandro A, Murphy MP, Mohorianu I, Pluchino S. Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature. 2024 Apr;628(8006):195-203. Epub 2024 Mar 13 PubMed.
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University of Kansas
This is an interesting paper, even though it is not directed toward Alzheimer’s disease. It does make some fundamental observations that are worth noting, and which are pertinent to Alzheimer’s. One is that mitochondrial function influences the activity and the status of immune cells. This is not a new observation, and there are multiple pathways through which mitochondria can influence inflammation and immunologic responses. The reverse electron transport phenomenon the author studied can be added to this canon.
Another is that mitochondria are important for free radical production, which certainly is an observed characteristic of AD. I also note that this study has potential relevance to drug development studies, such as those being pursued by Jania Trushina, in which some are looking at drugs that could potentially affect the reverse electron transport to treat AD.
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