Stem cells are defined by their function in complex microenvironments that are just beginning to be defined. The architecture of these anatomic sites in molecular, cellular and developmental terms has provided insight into how tissues are formed and maintained throughout life. They now provide an opportunity for examining settings of disease and offering a distinct group of possible therapeutic interventions. This meeting will examine select stem cell niches to explore unifying principles and identify opportunities for application in tissue regeneration and cancer therapy.

Upon completion of this meeting, participants should be able to

• discuss select stem cell anatomic sites in molecular, cellular and developmental terms;
• define stem cells in relationship to their functions within complex microenvironments;
• identify opportunities for application in tissue regeneration and cancer therapy.