All Comments by Hiroshi Mori

  1. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.
  2. Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.
  3. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
  4. Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric.
  5. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).
  6. Low prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia.
  7. Low prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia.
  8. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.
  9. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  10. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.
  11. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
  12. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
  13. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
  14. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement.
  15. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate.