Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Transcriptomes of more than 400 postmortem brains reveal microglia and astrocyte subtypes that collaborate to precipitate pathologic changes.
Transcriptomes of more than 400 postmortem brains reveal microglia and astrocyte subtypes that collaborate to precipitate pathologic changes.
XWAS from three research groups identified a dozen genetic loci that may help explain sex differences in AD.
Dynamic, lipid-rich inclusions of α-synuclein appear toxic, while stable, fibril-rich aggregates seem to protect neurons.
A new strategy, which marries nanobodies or misfolded tau to a ubiquitin ligase RING domain, tags tangles for disposal.
The consortium has cranked out dozens of mouse models of late-onset AD for the research community. Strains carry humanized Aβ and tau, and a growing list of risk variants.
A retrospective study finds that gut damage precedes Parkinson’s disease onset, independent of bacterial infection.
This super-sized isoform resists phosphorylation and aggregation, and occurs in cerebellum and brainstem, regions largely spared from tau pathology.
The indefatigable Colombian neurologist leaves behind a legacy of Alzheimer’s prevention research, which, at the time of his passing, stands on the cusp of success.
The days have cooled but the science presented in Philadelphia last July has not. As you hurtle into fall, sit back one more time and peruse our spread of 20 AAIC stories, which we just completed with an update on new mouse lines modeling late-onset AD. Plasma markers are ready for prime time, immunotherapies hold promise for disease prevention, and a clearer picture of the cellular phase of Alzheimer’s is emerging. Read our full coverage online or download the PDF.
Sporadic Alzheimer’s is a complex disease caused by a convergence of genetic, environmental, and health factors that may vary from person to person. To model this heterogeneity and pave the way for medicines targeting different manifestations, the MODEL-AD consortium has been churning out lines strapped with different AD risk variants. Recent published findings and presentations at AAIC highlight a growing catalogue of mouse models widely available to researchers.
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