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Adding Dynamics and Nuance to Alzheimer’s Staging

Being able to image amyloid, glucose metabolism, atrophy, even network connectivity in living patients has been a boon for those trying to stage the progression of Alzheimer’s disease. Using magnetic resonance imaging (MRI) and positron emission ...

Evolution of AD Trials

In a sign that researchers are grappling with therapy development, the 4th International Conference on Clinical Trials on Alzheimer's Disease was filled beyond the capacity of its venue, drawing 522 researchers from around the globe. Held 3-5 ...

Clearing the Fog Around Aβ Oligomers

Like calling a spade a spade? What about an Aβ oligomer? The study of this peptide’s oligomers has taken off in the last decade. Many labs have developed their own favorite means of making, purifying, and studying them. Researchers have isolated dimers, ...

Resolving Controversies on the Path to AD Therapeutics

Alzforum was pleased to partner with the journals Nature Medicine and Nature Reviews Drug Discovery in hosting a Webinar panel discussion on Thursday, 29 September 2011. At issue were a Perspective article by Dennis Selkoe on "Resolving controversies ...

Slow Aβ Clearance Is ApoE4’s Modus Operandi in Late-Onset AD

Alzforum has been pleased to partner with the journal Science Translational Medicine in hosting a Webinar discussion of a new Alzheimer’s disease research study published 29 June 2011. The journal generously granted free access to Castellano et al. for ...

Intraneuronal Aβ: Was It APP All Along?

On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus

Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for ...

Grasping the Shadow Force: Immune Cells in ALS

When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists ...

Herpes Simplex and Alzheimer’s—Time to Think Again?

On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared ...

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

The formation of cytoplasmic inclusions called stress granules is one of nature’s many ways of coping with adverse situations. It appears that these inclusions sequester non-essential messenger RNAs, allowing cells to focus on making proteins, such as ...

The AD8—Dementia Screen Ready for Prime Time?

Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against ...

Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.

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