Introduction

Gordon Shepherd and Kei Cheung from Yale University led this Web seminar. Our featured presenters provided an introduction to SenseLab, which is a long-standing database project to build integrated multidisciplinary models of neurons and neural systems.

SenseLab consists of a group of sub-databases. This seminar focused on the one called NeuronDB, which is a dynamically searchable database of three types of neuronal properties: voltage-gated conductances, neurotransmitter receptors, and neurotransmitter substances. In addition, the seminar described a new database called BrainPharm, which is under development and contains information about pharmacological agents that act on neuronal receptors and signal transduction pathways in the normal brain and in disorders such as Alzheimer disease. Drs. Shepherd and Cheung demonstrated a pilot Web interface that allows integrated queries to be performed between NeuronDB and BrainPharm. They showed how this enables one to navigate smoothly among NeuronDB, BrainPharm, and Alzforum to identify much more effectively than has been possible up to now the membrane properties in critical sites in cortical neurons that are affected by the neuropathogenesis of Alzheimer's. Finally, they discussed their recent effort on Semantic Web development of SenseLab, and showed a pilot demo of how to use the Semantic Web technology to integrate data from BrainPharm with data from Alzforum.

You will need Windows Media Player (PC Mac) to view this presentation.

Gordon Shepherd and Kei Cheung led this Webinar on 26 October 2006. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.

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References

Webinar Citations

  1. Webinar: The NeuronDB Knowledge Base

Other Citations

  1. View Presentation

External Citations

  1. PC
  2. Mac

Further Reading

Papers

  1. . Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Nat Genet. 1999 May;22(1):16-7; author reply 21-2. PubMed.
  2. . Alpha-2 macroglobulin gene and Alzheimer disease. Nat Genet. 1999 May;22(1):17-9; author reply 21-2. PubMed.
  3. . An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nat Genet. 1999 May;22(1):19-22. PubMed.