Introduction

Ben Wolozin of the Boston University School of Medicine presented some results from analyzing a 4.5 million-subject database of medical records to identify medications that are associated with reduction or increase in the incidence of dementia. His team's most recent study confirmed previous reports which suggested that statin (cholesterol-lowering) drugs may be protective. What's more, the new analysis found interesting differences among statin drugs. Simvastatin, for example, appears to significantly reduce the incidence of dementia only among individuals who do not have hypertension. These findings were presented at the recent International Conference on Alzheimer's Disease in Madrid, Spain (see abstract below). We also discussed issues relating to mining large health-record databases for insight into factors that influence the development of Alzheimer disease.

Ben Wolozin led this Webinar on 25 August 2006. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.

Background

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Background

Statins use is associated with a reduction in the incidence of dementia Benjamin Wolozin1*, Stan Wang2, Austin Wang4, Todd Lee3 and Lewis Kazis2,4 1Boston University School of Medicine, 2Bedford Veterans Affairs Medical Center, 3Hines Veterans Affairs Medical Center and 4Boston University School of Public Health Abstract We have analyzed the decision support system of the US Veterans Affairs database, which continues diagnostic, medication and demographic information on 4.5 million subjects, to examine whether statins are associated with a reduced incidence of dementia. We observed that simvastatin and lovastatin are associated with a reduced incidence of dementia in subjects 65 years or older after adjustment for hypertension, cardiovascular disease, diabetes and obesity. The odds ratio for incident dementia for simvastatin is 0.723 (CI 0.657 – 0.795, p

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References

News Citations

  1. Statin Use and Alzheimer Disease: A Tale of Two Methodologies?
  2. Atorvastatin, Vaccine Trial Data Published
  3. Philadelphia: All Is Not Well with the Statin Story
  4. Statins and AD—What Role Isoprenoids?
  5. Statins Boost α-Secretase, but Not Through Cholesterol

Webinar Citations

  1. Data-mining for Medications That Affect the Incidence of Dementia

Further Reading

Papers

  1. . Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 1998 Jan 22;391(6665):387-90. PubMed.