Protein Folding and Neurodegeneration: Biophysics to the Rescue?

30 Apr 2003

molecule as a recent (Apr 18) Science paper mentions and the article by Charlie Glabe of 1994

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

Medical School, Worcester, MA 01605 Zuoshang Xu led this live discussion on 18 March 2003. Readers are

Probing PPARγ? Agonists: Could Diabetes Drugs Treat Alzheimer's Disease?

• 1 Comment

16 Dec 2002

with 30 patients. The study uses pioglitazone at 45 mg/day for 18 months. The primary outcome measures

How the Other Half Lives—Or the What, How, and Where of the AβPP Intracellular Domain

• 1 Comment

20 Sep 2002

Leissring: Kalpana White has done the most work in this area. Torroja et al., J Neurosci 19(18):7793 is one.

Neural Stem Cells to the Rescue—Can Neuroreplacement Ever Become a Treatment for Alzheimer's?

09 Jul 2002

and recovery of cognitive function, Behavioral and Brain Sciences, 18 (1995) 10-35. 0 Tuesday, July 9,

Vascular Disease, Parkinson's, and Now Alzheimer's—Is Homocysteine the New All-Around Bad Guy?

• 1 Comment

12 May 2002

deficiency in AβPP-mutant mice in old age of your mice (about 18 months), but before amyloid deposition? Just

Cerebrometabolic Deficiency in Alzheimer's Disease

• 2 Comments

22 Apr 2002

2-[18F]fluoro-2-deoxyglucose/positron-emission tomography (FDC/PET). Proc Natl Acad Sci USA 2001;(98):10966-10971. Abstract. 13. Kumar A,

The Neuroplasticity Theory of Alzheimer's Disease

• 1 Comment

08 Apr 2002

J. Wesson Ashford led this live discussion on 8 April 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Tuesday, 8 April 2002 Participants: John Wesson Ashford (W

From Epidemiology to Therapeutic Trials with Anti-inflammatory Drugs in Alzheimer's Disease: The Role of NSAIDs and Cyclooxygenase on Beta-amyloidosis and Clinical Dementia

• 4 Comments

20 Mar 2002

Giulio Maria Pasinetti led this live discussion on 20 February 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.   See Related News Story: NO-Releasing NSAID Reduces β-Amyloid, Activates Microgli

The Role of ApoE in Alzheimer's Disease: An Alternative View

11 Dec 2001

cultures. J Neurosci 18: 195-204. Abstract LaDu MJ, Falduto MT, Manelli AM, Reardon CA, Getz GS, Frail DE

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

Live discussion and panel of participants scheduled for 7 September 2001.     Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe

Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein

20 Sep 2000

cleavage of poly [ADR-ribose] polymerase (PARP) by cell death protease known as caspases (18) also

Intracellular Aβ in Alzheimer's Disease

• 3 Comments

16 May 2000

Gunnar Gouras led this live discussion on 16 May 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held 16 May 2000.   Participants: Bruce Yankner, Huaxi Xu, Austin Ya

Beta-Catenin and PS1

13 Aug 1999

Chris Weihl, with Bruce Yankner, Benjamin Wolozin, Eddie Koo, and Kenneth Kosik led this live discussion on 13 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion

Pin1, Tau and the Cell Cycle in Alzheimer Disease

03 Aug 1999

15;18:2801-2807. Abstract. 2. Campbell HD, Webb GC, Fountain S, Young IG. The human PIN1 peptidyl-prolyl cis/trans