Leaky Blood-Brain Barrier a Harbinger of Alzheimer's?
DCE-MRI scans of six healthy young people, 18 older folks who were cognitively normal, and 21 older adults
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Good-Bye Overexpression, Hello APP Knock-in. A Better Model?
knock-in mice were losing synapses. Beginning at 18 months, NL-F mice had trouble learning the location of
Webinar: O Blood-Based Biomarker, Where Art Thou?
neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study. Molecular Psychiatry (2013), 1–8
New Frontier: Developing Outcome Measures for Pre-dementia Trials
lengths for clinical trials of potential disease-modifying therapies in MCI would be one year, 18 months,
Latest γ-Secretase Substrate Involved in Synaptic Stability, Autism?
of Neuroligin 1. 18 Oct 2012;76:410-422. Free Access at Cell Press Peixoto R, Kunz PA, Kwon H, Mabb
Who Should Use the New Diagnostic Guidelines? The Debate Continues
cortex on [18]flurodeoxyglucose (FDG) positron emission tomography c) atrophy on MRI
Adding Dynamics and Nuance to Alzheimer’s Staging
18F-AV-45 (florbetapir F-18), an agent currently under consideration by the U.S. Food and Drug
Slow Aβ; Clearance Is ApoE4’s Modus Operandi in Late-Onset AD
number one genetic risk factor for late-onset Alzheimer’s disease (see AlzGene Top Results), yet 18 years
Intraneuronal Aβ: Was It APP All Along?
peptides, induces neuronal apoptosis. J Biol Chem. 2002 May 3;277(18):15666-70. Abstract Leon WC, Canneva F,
Reimagining Alzheimer's Disease—Time for Bright New Ideas?
Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger
Herpes Simplex and Alzheimer’s—Time to Think Again?
On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared som
Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)
This Webinar recapped the latest research in this area. Michael Heneka of the University of Bonn, Germany, and Doug Feinstein of the University of Illinois, Chicago, gave presentations, and were joined in a panel discussion by Virgil Muresan, New Jersey M
Betwixt and Intermixed—Dementia With Lewy Bodies
On 15 June 2009, we hosted a Webinar discussion with slide presentations by Ian McKeith at Newcastle University, UK, James Leverenz at University of Washington, Seattle, James Galvin, Washington University, St. Louis, Brit Mollenhauer of Paracelsus-Elena
Meet New Players, Histone Deacetylase and Sirtuin—Will They Help the Cell Cycle, DNA Repair, and Gene Expression Break Into Alzheimerology’s Major League?
but alters gene expression during aging. Cell. 2008 Nov 28;135(5):907-18. Abstract 0 Thursday,
Calcium in AD Pathogenesis
A Live Webinar Discussion was held on 29 October 2008, with presentations from Ilya Bezprozvanny, Beth Stutzmann, Kevin Foskett, Kim Green, and Brian Bacskai and Kishore Kuchibhotla. This live discussion began with a Webinar featuring a slide talk with au
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.
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