Therapeutics

This database provides a catalog of the therapeutics currently or previously tested as treatment for Alzheimer's disease and related disorders, focusing on those that have progressed to Phase 2 or beyond in U.S. clinical trials. We strive to keep this database up-to-date and welcome you to contact us at therapeutics@alzforum.org.

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AD Target / Therapy Types

The two tables below organize the therapeutics within this database by therapy type and proposed target type. The number of therapeutics within each category is indicated according to the highest phase each therapeutic has achieved in U.S. clinical trials. For example, if a given therapeutic is in both Phase 2 and Phase 3 trials, it is included in the Phase 3 total.

Target Type

Therapy Type

Therapy Types Timeline Phase 1 Phase 2 Phase 2/3 Phase 3 Phase 4 Approved Inactive Discontinued Total
Small Molecule 2 25 1 9 2 5 17 42 103
Immunotherapy (active) View Timeline 0 2 0 0 0 0 0 2 4
Immunotherapy (passive) View Timeline 2 3 1 2 0 0 0 3 11
Gene/Stem Cell 0 1 0 0 0 0 0 0 1
Procedural Intervention 0 2 0 1 0 0 1 0 4
Dietary Supplement 0 3 0 4 1 0 2 1 11
Other 0 4 0 0 0 0 1 2 7

Further Reading

News

  1. Could Bolstering the Retromer Thwart Alzheimer’s?
  2. PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial
  3. Coenzyme Q10 Strikes Out in Phase 3 for Parkinson’s
  4. BACE Inhibitor Heads for Phase 2/3 Trials

Webinars

  1. Resolving Controversies on the Path to AD Therapeutics
  2. Treating Before Symptoms—ADCS Invites Ideas for Clinical Trials in Very Early AD
  3. Of Mice and Men: Bridging the Translational Disconnect in CNS Drug Discovery
  4. Can We (Should We?) Develop “Smart Drugs” to Stave Off Age-Related Memory Loss?

Other Resources

ADDF ACCESS is a program to provide scientists in academia and small biotechnology companies with access to a virtual network of drug discovery experts and contract research organizations (CROs) that have experience developing therapies for neurodegenerative diseases.

Patient Resources page is a collection of web sites that can provide assistance and support for Alzheimer patients, their families and caregivers.

Patient Resources