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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-126 2 AbbVie Cholinergic System Small Molecule Alzheimer's Disease
ABT-288 Discontinued AbbVie Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
Acitretin Soriatane , Neotigason, RO 101670 2 Stiefel Laboratories, Inc. APP and Amyloid-Related Small Molecule Alzheimer's Disease Psoriasis in US
AF 102B cevimeline HCL, Evoxac™ Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
AQW051 Alpha-7 nicotinic acetylcholine receptor agonist Inactive, 2, 2 Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Alzheimer's Disease, Parkinson's Disease, Schizophrenia
Atomoxetine ATX, Strattera Discontinued Eli Lilly & Co. Other Neurotransmitter Systems Small Molecule Alzheimer's Disease ADHD in US
Atorvastatin Lipitor™ , Zarator®, Sortis®, Tahor® Inactive Pfizer Cholesterol Small Molecule Alzheimer's Disease Hypercholesterolaemia
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb APP and Amyloid-Related Small Molecule Alzheimer's Disease
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
AZD3293 BACE1 inhibitor 1 AstraZeneca APP and Amyloid-Related Small Molecule Alzheimer's Disease
AZD3480 ispronicline, TC-1734 Inactive AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
Bexarotene Targretin® 2 Unknown Small Molecule Mild Cognitive Impairment Cutaneous T-cell Lymphoma in US
Brexpiprazole OPC 34712 3 Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
Carvedilol Carvil (Zydus Cadila), Coreg (GSK), Dilatrend (Roche), Eucardic (Roche), Carloc (Cipla) 4 Unknown Small Molecule Alzheimer's Disease
CHF 5074 2, Inactive CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. APP and Amyloid-Related, Inflammation, Other Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
Circadin 2 Neurim Pharmaceuticals Ltd. Other Small Molecule Alzheimer's Disease Insomnia in US
Clioquinol iodochlorhydroxyquin, PBT-1 Discontinued Metals Small Molecule Alzheimer's Disease none
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitter Systems Small Molecule Alzheimer's Disease None
Dapsone Avlosulfon, Diaminodiphenylsulfone, DDS Inactive Immune Network Ltd. Other Small Molecule Alzheimer's Disease Leprosy, malaria, some bacterial skin infections
Dimebon Dimebolin, Latrepirdine, Pf-01913539 Inactive Medivation, Inc. Unknown Small Molecule Alzheimer's Disease Anti-histamine use in Russia
Donepezil Aricept™, Donepezil hydrochloride, Eranz®, E 2020 Approved, 3, 2, 3 Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies, Down Syndrome, Parkinson's Disease Dementia Alzheimer's Disease
E2609 BACE1 inhibitor 1, Discontinued Eisai Co., Ltd. APP and Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
EHT 0202 Etazolate 2 ExonHit Therapeutics Other Small Molecule Alzheimer's Disease None
ELND005 AZD-103, Scyllo-inositol, cyclohexane-1,2,3,4,5,6-hexol 2 Elan Corporation, Speranza Therapeutics APP and Amyloid-Related Small Molecule Alzheimer's Disease None
Encenicline EVP-6124 , MT-4666, α7-nAChR agonist 3, 3 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals), Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Epothilone D BMS-241027 1 Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
EVP-0962 EVP 0015962 2, 2 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals) APP and Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Exendin-4 Exenatide, Byetta, Bydureon 2 Other Small Molecule Alzheimer's Disease Diabetes mellitus in US
Flurizan™ tarenflurbil , r-flurbiprofen, MPC-7869 Discontinued Myriad Genetics & Laboratories APP and Amyloid-Related Small Molecule Alzheimer's Disease None
G-CSF Filgrastim 2 Other Small Molecule Alzheimer's Disease Neutropenia in US
Galantamine Razadyne™, Reminyl™, Nivalin® Approved Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Alzheimer's Disease Mild to Moderate Alzheimer's disease
GSK239512 Discontinued GlaxoSmithKline (GSK) Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
HF0220 Discontinued Hunter-Fleming Ltd (now Newron) Inflammation Small Molecule Alzheimer's Disease
Huperzine A ZT-1, DEBIO 9902 , Qian ceng ta, Cerebra capsule, Pharmassure Memorall capsule Inactive Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Dietary Supplement Alzheimer's Disease None
Ibuprofen Advil™, Nuprin™ , Motrin™ Discontinued Inflammation Small Molecule Alzheimer's Disease None
Idebenone Catena, Sovrima Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
Ladostigil Hemitartrate TV-3,326 2 Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule Mild Cognitive Impairment
Levetiracetam Keppra 2, Discontinued GlaxoSmithKline (GSK), Otsuka Pharmaceutical Co., Ltd., UCB S.A. APP and Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Liraglutide Victoza™ 2 Novo Nordisk A/S Other Small Molecule Alzheimer's Disease
Lornoxicam Discontinued, Discontinued JSW Lifesciences Inflammation Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Pain in US
Lu AE58054 SGS 518 3, Inactive Eli Lilly & Co., Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitter Systems Small Molecule Alzheimer's Disease, Schizophrenia
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
LY2886721 β-secretase inhibitor Discontinued, Discontinued Eli Lilly & Co. APP and Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
Masitinib Masivet, Kinavet, AB1010, Masitinib mesylate 3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
Memantine Ebixa™, Namenda™ , Axura®, Akatinol®, Memary® Approved Forest Laboratories, Inc., Lundbeck, Merz Pharma Other Neurotransmitter Systems Small Molecule Alzheimer's Disease Alzheimer's Disease
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
Minocycline Solodyn, Arestin, Minocin, Dynacin 2 Inflammation Small Molecule Alzheimer's Disease
MK-7622 2 Merck Unknown Small Molecule Alzheimer's Disease
MK-8931 MK-8931-009 , β-secretase inhibitor 3 Merck APP and Amyloid-Related Small Molecule Alzheimer's Disease
MKC-231 Inactive Mitsubishi Tanabe Pharma Unknown Small Molecule Alzheimer's Disease None
MSDC-0160 Mitoglitazone 2 Metabolic Solutions Development Company Other Small Molecule Alzheimer's Disease
Naproxen Aleve™, Anaprox™, Naprosyn™ Discontinued Procter & Gamble, Roche Products (Ireland) Limited Inflammation Small Molecule Alzheimer's Disease Over the counter drug for reduction of pain, fever, inflammation, and stiffness.
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
NeoTrofin AIT-082, leteprinim Discontinued NeoTherapeutics, Inc. Unknown Small Molecule Alzheimer's Disease None
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitter Systems Small Molecule Alzheimer's Disease None
NGX267 AF267B Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease None
NIC5-15 Pinitol, D-Pinitol 2 Humanetics Pharmaceuticals Corporation APP and Amyloid-Related, Other Small Molecule, Dietary Supplement Alzheimer's Disease
Nicotinamide Enduramide, Niacinamide, Nicotinic acid amide, Vitamin B3 2 Other Small Molecule Alzheimer's Disease
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
ORM-12741 2 Orion Pharma Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
PBT2 2, 2 Prana Biotechnology Limited APP and Amyloid-Related, Metals Small Molecule Alzheimer's Disease, Huntington's Disease
PF-05212377 PF-5212377, WYE-103760, SAM-760 2 Pfizer Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
Phenserine Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Pioglitazone AD4833, Actos®, Glustin™, Piozone® 3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
Prednisone 3 Inflammation Small Molecule Alzheimer's Disease
Propentofylline HWA 285, PPF Discontinued Unknown Small Molecule Alzheimer's Disease
PRX-03140 Potassium salt Inactive Epix Pharmaceuticals Other Small Molecule Alzheimer's Disease
R-pramipexole RPPX, Dexpramipexole, KNS-760704 , BIIB 050 2, Discontinued Biogen Idec, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitter Systems, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Rember TM Methylene Blue, Tau aggregation inhibitor (TAI), TRx-0014 Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
Resveratrol trans-3,4',5-trihydroxystilbene 3 Other Small Molecule Alzheimer's Disease
RG3487 RO5313534, MEM 3454 Inactive Roche Products (Ireland) Limited Cholinergic System Small Molecule Alzheimer's Disease
RG7129 RO5508887, BACE1 Inhibitor Discontinued Roche Products (Ireland) Limited APP and Amyloid-Related Small Molecule Alzheimer's Disease
Rilapladib SB-659032 2 GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Riluzole Rilutek®, RP 54274 2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitter Systems, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
Rivastigmine Exelon™, Rivastigmine tartrate , Rivastach® Patch, Prometax®, SDZ ENA 713 Approved, Approved Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Alzheimer's Disease, Parkinson's Disease Dementia Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Rofecoxib Vioxx™ Discontinued Merck Inflammation Small Molecule Alzheimer's Disease
Rosiglitazone Rosiglitazone maleate Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Sabeluzole R58735 Inactive Unknown Small Molecule Alzheimer's Disease
SAR110894D 2 Sanofi Other Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
SB-742457 GSK 742457 Inactive, 2 GlaxoSmithKline (GSK) Other Neurotransmitter Systems Small Molecule Alzheimer's Disease, Dementia
Semagacestat LY450139 Dihydrate , hydroxylvaleryl monobenzocaprolactam Discontinued Eli Lilly & Co. APP and Amyloid-Related Small Molecule Alzheimer's Disease None
SGS-742 CGP-36742, DVD-742 Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
Simvastatin Zocor®, Lipex®, Lipovas®, Denan® Inactive, 4 Merck Cholesterol Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Hypercholesterolemia and diabetic cardiomyopathy.
ST101 ZSET1446 Inactive Sonexa Therapeutics, Inc. Unknown Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitter Systems Small Molecule Alzheimer's Disease
T-817MA 2 Toyama Chemical Co., Ltd. Unknown Small Molecule Alzheimer's Disease
Tacrine Cognex™ Approved Cholinergic System Small Molecule Alzheimer's Disease
Thalidomide Thalomid® 2/3 Celgene Corporation APP and Amyloid-Related, Inflammation Small Molecule Alzheimer's Disease
Tideglusib NP031112, Nypta® , Zentylor™ , Glycogen synthase kinase 3 inhibitor, NP12 Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy
TRx0237 LMT-X, Methylene Blue, Tau aggregation inhibitor (TAI) 3, 3 TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease, Frontotemporal Dementia Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
TTP488 PF-04494700 , RAGE Inhibitor Inactive Pfizer, TransTech Pharma, Inc. APP and Amyloid-Related Small Molecule Alzheimer's Disease
Valproate Depakote, Depakene, Valproic acid , Divalproex sodium Inactive Abbott Laboratories Other Neurotransmitter Systems Small Molecule Alzheimer's Disease Epilepsy, Bipolar disorder, Migraine
Varenicline Champix™, Chantix™, Varenicline tartrate, CP-526,555, Alpha4 beta2 nicotinic receptor agonist Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation