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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT-288 Discontinued AbbVie Other Neurotransmitters Small Molecule Alzheimer's Disease
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Brexpiprazole OPC 34712 3 Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
GSK239512 Discontinued GlaxoSmithKline (GSK) Other Neurotransmitters Small Molecule Alzheimer's Disease
Lu AE58054 SGS 518 3, Inactive Eli Lilly & Co., Lundbeck, Otsuka Pharmaceutical Co., Ltd. Other Neurotransmitters Small Molecule Alzheimer's Disease, Schizophrenia
Memantine Ebixa™,
Namenda™ ,
Axura®,
Akatinol®,
Memary®
Approved Forest Laboratories, Inc., Lundbeck, Merz Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease Alzheimer's Disease
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
ORM-12741 2 Orion Pharma Other Neurotransmitters Small Molecule Alzheimer's Disease
PF-05212377 PF-5212377,
WYE-103760,
SAM-760
2 Pfizer Other Neurotransmitters Small Molecule Alzheimer's Disease
Prazosin Prazosin hydrochloride,
Minipress,
Hypovase,
Vasoflex
4 Other Neurotransmitters Small Molecule Alzheimer's Disease Hypertension
R-pramipexole RPPX,
Dexpramipexole,
KNS-760704 ,
BIIB 050
2, Discontinued Biogen Idec, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Riluzole Rilutek®,
RP 54274
2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
SB-742457 GSK 742457 Inactive, 2 GlaxoSmithKline (GSK) Other Neurotransmitters Small Molecule Alzheimer's Disease, Dementia
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Valproate Depakote,
Depakene,
Valproic acid ,
Divalproex sodium
Inactive Abbott Laboratories Other Neurotransmitters Small Molecule Alzheimer's Disease Epilepsy, Bipolar disorder, Migraine