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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
AC-1204 Caprylic triglyceride,
Long-chain triglycerides
2/3 Accera, Inc. Other Dietary Supplement Alzheimer's Disease None
Acetyl-l-carnitine HCI ALCAR Discontinued Sigma-Tau Pharmaceuticals Other Dietary Supplement Alzheimer's Disease
Alpha-Tocopherol Vitamin E 3 Other Dietary Supplement Alzheimer's Disease
CERE-110 Nerve Growth Factor gene therapy 2 Ceregene, Inc. Other Gene/Stem Cell Alzheimer's Disease
Cerebrolysin 2 Ebewe Pharmaceutical Other Other Alzheimer's Disease
CHF 5074 2, Inactive CereSpir™ Incorporated, Chiesi Pharmaceuticals Inc. Amyloid-Related, Inflammation, Other Small Molecule Mild Cognitive Impairment, Alzheimer's Disease
Circadin 2 Neurim Pharmaceuticals Ltd. Other Small Molecule Alzheimer's Disease Insomnia in US
COGNIShunt™ Inactive Other Procedural Intervention Alzheimer's Disease None
Curcumin diferuloylmethane,
Longvida™
2 Verdure Sciences Other, Unknown Dietary Supplement Alzheimer's Disease None
Dapsone Avlosulfon,
Diaminodiphenylsulfone,
DDS
Inactive Immune Network Ltd. Other Small Molecule Alzheimer's Disease Leprosy, malaria, some bacterial skin infections
Docosahexaenoic acid (DHA) Omega 3 fatty acid 4, Not Regulated Martek Biosciences Corporation, NeuroBioPharm, Inc. Other Dietary Supplement Alzheimer's Disease,
EHT 0202 Etazolate 2 ExonHit Therapeutics Other Small Molecule Alzheimer's Disease None
Epigallocatechin Gallate (EGCG) Sunphenon EGCg 2/3, 2, 3 Taiyo International Amyloid-Related, Inflammation, Other Dietary Supplement Alzheimer's Disease, Down's Syndrome, Multiple System Atrophy
Estrogen Premarin™ Discontinued Other Other Alzheimer's Disease Hormone Replacement Therapy
Etanercept Enbrel™ 2 Amgen, Inc., Pfizer Other Other Alzheimer's Disease Rheumatoid Arthritis,Polyarticular Juvenile Idiopathic Arthritis,Psoriatic Arthritis
Exendin-4 Exenatide,
Byetta,
Bydureon
2 Other Small Molecule Alzheimer's Disease Diabetes mellitus in US
G-CSF Filgrastim 2 Other Small Molecule Alzheimer's Disease Neutropenia in US
Idebenone Catena,
Sovrima
Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
Ketasyn Axona,
Caprylic Acid,
AC-1202
4 Accera, Inc. Other Dietary Supplement Alzheimer's Disease
Leuprolide Leuprolide acetate Discontinued Other Other Alzheimer's Disease None
Levetiracetam Keppra 2, Discontinued GlaxoSmithKline (GSK), Otsuka Pharmaceutical Co., Ltd., UCB S.A. Amyloid-Related, Other Small Molecule Mild Cognitive Impairment, Parkinson's Disease Epilepsy and Partial Seizures in U.S., European Union, plus about 20 other countries
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Liraglutide Victoza™ 2 Novo Nordisk A/S Other Small Molecule Alzheimer's Disease
Masitinib Masivet,
Kinavet,
AB1010,
Masitinib mesylate
3, 3 AB Science Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Melatonin 2 Other Dietary Supplement Alzheimer's Disease None
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
MSDC-0160 Mitoglitazone 2 Metabolic Solutions Development Company Other Small Molecule Alzheimer's Disease
Nasal Insulin Detemir,
Levemir,
Humulin,
Novolin
2, 2, 2, 2 Amyloid-Related, Other Small Molecule, Other Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple System Atrophy Diabetes
NIC5-15 Pinitol,
D-Pinitol
2 Humanetics Pharmaceuticals Corporation Amyloid-Related, Other Small Molecule, Dietary Supplement Alzheimer's Disease
Nicotinamide Enduramide,
Niacinamide,
Nicotinic acid amide,
Vitamin B3
2 Other Small Molecule Alzheimer's Disease
Nilvadipine Nilvad,
Nivadil,
ARC029
3 Archer Pharmaceuticals, Inc. Other Small Molecule Alzheimer's Disease
Pioglitazone AD4833,
Actos®,
Glustin™,
Piozone®
3 Takeda Pharmaceutical Company, Zinfandel Pharmaceuticals Inc. Inflammation, Other Small Molecule Mild Cognitive Impairment Type 2 diabetes mellitus
PRX-03140 Potassium salt Inactive Epix Pharmaceuticals Other Small Molecule Alzheimer's Disease
R-pramipexole RPPX,
Dexpramipexole,
KNS-760704 ,
BIIB 050
2, Discontinued Biogen Idec, Knopp Biosciences LLC, Virginia Commonwealth University Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Amyotrophic Lateral Sclerosis
Repetitive Transcranial Magnetic Stimulation rTMS 2 Neuronix Ltd Other Procedural Intervention Alzheimer's Disease
Resveratrol trans-3,4',5-trihydroxystilbene 3, 4, Not Regulated Other Small Molecule, Dietary Supplement Alzheimer's Disease, Mild Cognitive Impairment,
Rilapladib SB-659032 2 GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
Riluzole Rilutek®,
RP 54274
2, Discontinued, Approved, Discontinued Sanofi Other Neurotransmitters, Other Small Molecule Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Huntington's Disease Amyotrophic Lateral Sclerosis in many countries
Rosiglitazone Rosiglitazone maleate Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
SAR110894D 2 Sanofi Other Small Molecule Alzheimer's Disease
Sargramostim Leukine®,
GM-CSF
2 Genzyme, Sanofi Inflammation, Other, Unknown Other Alzheimer's Disease Bone Marrow Stimulation
T-817MA T 817MA, T817MA 2 Toyama Chemical Co., Ltd. Other, Unknown Small Molecule Alzheimer's Disease