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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-126 2 AbbVie Cholinergic System Small Molecule Alzheimer's Disease
AF 102B cevimeline HCL,
Evoxac™
Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
AZD3480 ispronicline,
TC-1734
Inactive AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease
Donepezil Aricept™,
Donepezil hydrochloride,
Eranz®,
E 2020
Approved, 3, 2, 3 Eisai Co., Ltd., Pfizer Cholinergic System Small Molecule Alzheimer's Disease, Dementia with Lewy Bodies, Down Syndrome, Parkinson's Disease Dementia Alzheimer's Disease
Encenicline EVP-6124 ,
MT-4666,
α7-nAChR agonist
3, 3 FORUM Pharmaceuticals Inc. (was EnVivo Pharmaceuticals), Mitsubishi Tanabe Pharma Cholinergic System Small Molecule Alzheimer's Disease, Schizophrenia None
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
Galantamine Razadyne™,
Reminyl™,
Nivalin®
Approved Janssen, Ortho-McNeil Pharmaceutical, Sanochemia Pharmazeutika, Shire, Takeda Pharmaceutical Company Cholinergic System Small Molecule Alzheimer's Disease Mild to Moderate Alzheimer's disease
Huperzine A ZT-1,
DEBIO 9902 ,
Qian ceng ta,
Cerebra capsule,
Pharmassure Memorall capsule
Inactive Debiopharm Group™, Neuro-Hitech, Inc. Cholinergic System Small Molecule, Dietary Supplement Alzheimer's Disease None
Ladostigil Hemitartrate TV-3,326 2 Avraham Pharmaceuticals Ltd Cholinergic System Small Molecule Mild Cognitive Impairment
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
NGX267 AF267B Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease None
Phenserine Inactive TorreyPines Therapeutics, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
RG3487 RO5313534,
MEM 3454
Inactive Roche Cholinergic System Small Molecule Alzheimer's Disease
Rivastigmine Exelon™,
Rivastigmine tartrate ,
Rivastach® Patch,
Prometax®,
SDZ ENA 713
Approved, Approved Novartis Pharmaceuticals Corporation Cholinergic System Small Molecule Alzheimer's Disease, Parkinson's Disease Dementia Mild to moderate Alzheimer’s disease and mild to moderate dementia related to Parkinson's disease
Tacrine Cognex™ Approved Pfizer, Shionogi Pharma Cholinergic System Small Molecule Alzheimer's Disease
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation