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Name Synonyms FDA Status Company Target Type Therapy Type Condition Approved
For
ABT 418 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
ABT-089 Discontinued Abbott Laboratories Cholinergic System Small Molecule Alzheimer's Disease
ABT-288 Discontinued AbbVie Other Neurotransmitters Small Molecule Alzheimer's Disease
ABT-384 Discontinued AbbVie Other Small Molecule Alzheimer's Disease
AF 102B cevimeline HCL,
Evoxac™
Discontinued SnowBrand Pharmaceuticals, Inc. Cholinergic System Small Molecule Alzheimer's Disease Treatment of dry mouth in Sjogren's syndrome.
Atomoxetine ATX,
Strattera
Discontinued Eli Lilly & Co. Other Neurotransmitters Small Molecule Alzheimer's Disease ADHD in US
Avagacestat BMS-708163 Discontinued Bristol-Myers Squibb Amyloid-Related Small Molecule Alzheimer's Disease
AZD1446 TC-6683 Discontinued AstraZeneca, Targacept Cholinergic System Small Molecule Alzheimer's Disease None
Besipirdine HCl HP 749 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Clioquinol iodochlorhydroxyquin,
PBT-1
Discontinued Metals Small Molecule Alzheimer's Disease none
CX516 Ampalex Discontinued Cortex Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease None
Epothilone D BMS-241027 Discontinued Bristol-Myers Squibb Tau Small Molecule Alzheimer's Disease
Eptastigmine MF 201 Discontinued Mediolanum Cholinergic System Small Molecule Alzheimer's Disease None
Flurizan™ tarenflurbil ,
r-flurbiprofen,
MPC-7869
Discontinued Myriad Genetics & Laboratories Amyloid-Related Small Molecule Alzheimer's Disease None
GSK239512 Discontinued GlaxoSmithKline (GSK) Other Neurotransmitters Small Molecule Alzheimer's Disease
HF0220 Discontinued Hunter-Fleming Ltd (now Newron) Inflammation Small Molecule Alzheimer's Disease
Ibuprofen Advil™,
Nuprin™ ,
Motrin™
Discontinued Inflammation Small Molecule Alzheimer's Disease None
Idebenone Catena,
Sovrima
Discontinued Takeda Pharmaceutical Company Other Small Molecule Alzheimer's Disease None
Linopirdine DuP996 Discontinued Other Small Molecule Alzheimer's Disease None
Lornoxicam Discontinued, Discontinued JSW Lifesciences Inflammation Small Molecule Alzheimer's Disease, Mild Cognitive Impairment Pain in US
LU25-109 Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
LY2886721 β-secretase inhibitor Discontinued, Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease, Mild Cognitive Impairment
MEM 1003 BAY Z 4406 Discontinued, Discontinued, Discontinued, Discontinued Memory Pharmaceuticals Corporation Other Small Molecule Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Bipolar Disorder None
Metrifonate trichlorfon Discontinued Cholinergic System Small Molecule Alzheimer's Disease None
Milameline CI 979 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Cholinergic System Small Molecule Alzheimer's Disease None
Naproxen Aleve™,
Anaprox™,
Naprosyn™
Discontinued Procter & Gamble, Roche Inflammation Small Molecule Alzheimer's Disease Over the counter drug for reduction of pain, fever, inflammation, and stiffness.
Nefiracetam Discontinued Daiichi Sankyo Pharmaceuticals Cholinergic System Small Molecule Alzheimer's Disease None
NeoTrofin AIT-082,
leteprinim
Discontinued NeoTherapeutics, Inc. Unknown Small Molecule Alzheimer's Disease None
Neramexane MRZ 2/579 Discontinued Forest Laboratories, Inc., Merck Other Neurotransmitters Small Molecule Alzheimer's Disease None
NS2330 Tesofensine Discontinued NeuroSearch A/S Other Neurotransmitters Small Molecule Alzheimer's Disease
Physostigmine Salicylate Synapton Discontinued Forest Laboratories, Inc. Cholinergic System Small Molecule Alzheimer's Disease
Prednisone Discontinued Inflammation Small Molecule Alzheimer's Disease
Propentofylline HWA 285,
PPF
Discontinued Unknown Small Molecule Alzheimer's Disease
Rember TM Methylene Blue,
Tau aggregation inhibitor (TAI),
TRx-0014
Discontinued TauRx Therapeutics Ltd Tau Small Molecule Alzheimer's Disease Methylene Blue predates FDA. Used for treatment of malaria and methemoglobinemia.
RG7129 RO5508887,
BACE1 Inhibitor
Discontinued Roche Amyloid-Related Small Molecule Alzheimer's Disease
Rofecoxib Vioxx™ Discontinued Merck Inflammation Small Molecule Alzheimer's Disease
Rosiglitazone Rosiglitazone maleate Discontinued GlaxoSmithKline (GSK) Other Small Molecule Alzheimer's Disease
SB 202026 Memric Discontinued Other Neurotransmitters Small Molecule Alzheimer's Disease
Semagacestat LY450139 Dihydrate ,
hydroxylvaleryl monobenzocaprolactam
Discontinued Eli Lilly & Co. Amyloid-Related Small Molecule Alzheimer's Disease None
SGS-742 CGP-36742,
DVD-742
Discontinued Novartis Pharmaceuticals Corporation, Saegis Pharmaceuticals, Inc. Other Neurotransmitters Small Molecule Alzheimer's Disease
Suritozole MD 26479 Discontinued Aventis Pharmaceuticals, Inc. (was Hoechst) Other Neurotransmitters Small Molecule Alzheimer's Disease
Tideglusib NP031112,
Nypta® ,
Zentylor™ ,
Glycogen synthase kinase 3 inhibitor,
NP12
Discontinued, Discontinued Zeltia Group Tau Small Molecule Alzheimer's Disease, Progressive Supranuclear Palsy
Varenicline Champix™,
Chantix™,
Varenicline tartrate,
CP-526,555,
Alpha4 beta2 nicotinic receptor agonist
Discontinued Pfizer Cholinergic System Small Molecule Alzheimer's Disease Smoking cessation