Therapeutics

Rosiglitazone

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Overview

Name: Rosiglitazone
Synonyms: Rosiglitazone maleate
Chemical Name: 5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione, AVANDIA®
Therapy Type: Small Molecule (timeline)
Target Type: Other (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: GlaxoSmithKline (GSK)

Background

Rosiglitazone is an antidiabetic agent that lowers blood glucose by improving target cell response to insulin, without increasing pancreatic insulin secretion. It is an agonist for peroxisome proliferator-activated receptor-γ (PPARγ) a nuclear receptor predominantly expressed in adipose tissue. Activation of PPARγ receptors influences the expression of a number of genes involved in glucose and lipid metabolism.

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