Therapeutics

Propentofylline

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Overview

Name: Propentofylline
Synonyms: HWA 285, PPF
Therapy Type: Small Molecule
Target Type: Unknown
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)

Background

Propentofylline is a xanthine derivative that inhibits adenosine uptake and also inhibits phosphodiesterase. It exerts inhibitory activity on the proliferation of microglial cells, the formation of oxygen free radicals, and the release of inflammatory cytokines. [Cochrane Library]

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