Therapeutics

NS2330

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Overview

Name: NS2330
Synonyms: Tesofensine
Therapy Type: Small Molecule (timeline)
Target Type: Other Neurotransmitters (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: NeuroSearch A/S

Background

NS2330 is a monoamine uptake inhibitor that inhibits norepinephrine, serotonin, and dopamine reuptake. Tesofensine inhibits the presynaptic uptake of these monoamine neurotransmitters and stimulates the cholinergic system indirectly (Lehr et al., 2008).

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References

Paper Citations

  1. . Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach. Br J Pharmacol. 2008 Jan;153(1):164-74. PubMed.

Further Reading

No Available Further Reading