Therapeutics

NS2330

Tools

Back to the Top

Overview

Name: NS2330
Synonyms: Tesofensine
Therapy Type: Small Molecule (timeline)
Target Type: Other Neurotransmitters (timeline)
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Company: NeuroSearch A/S

Background

NS2330 is a monoamine uptake inhibitor that inhibits norepinephrine, serotonin, and dopamine reuptake. Tesofensine inhibits the presynaptic uptake of these monoamine neurotransmitters and stimulates the cholinergic system indirectly (Lehr et al., 2008).

Last Updated: 12 Dec 2013

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

References

Paper Citations

  1. Lehr T, Staab A, Tillmann C, Nielsen EØ, Trommeshauser D, Schaefer HG, Kloft C. Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach. Br J Pharmacol. 2008 Jan;153(1):164-74. PubMed.

Further Reading

No Available Further Reading