Chemical Name: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one
Therapy Type: Small Molecule
Target Type: Other
Condition(s): Alzheimer's Disease
U.S. FDA Status: Alzheimer's Disease (Discontinued)
Approved for: None
Linopirdine increases acetylcholine release in rat brain (Schnee & Brown, 1998). The mechanism is thought to involve linopirdine's inhibition of voltage-gated, calcium-activated, and leak K-positive currents, especially the M-type K-oositive current (IM) (Schnee & Brown, 1998).
- Schnee ME, Brown BS. Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. PubMed.
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