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Debby Tsuang
University of WashingtonSeattle, United States
Anne Urfer-Buchwalder
Selonterra LLC
Astrocytes Agitate Neurons in Huntington’s Disease
RESEARCH NEWS 2014-03-31 Research News Studies of neurodegenerative disease often overlook astrocytes, the glial cells that surround and nurture neurons. For some years, evidence has grown to suggest they play an important role. Now, in the March 30 Nature Neuroscience, researche
PAPER Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT
Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3811-6. Epub 2010 Feb 2 PubMed: 20133576PAPER Puwarawuttipanit W, Bragg AD, Frydenlund DS, Mylonakou MN, Nagelhus EA, Peters MF, Kotchabhakdi N, Adams ME, Froehner SC, Haug FM, Ottersen OP, Amiry-Moghaddam M
Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice.
Neuroscience. 2006;137(1):165-75. Epub 2005 Oct 28 PubMed: 16257493PAPER Barres BA, Koroshetz WJ, Chun LL, Corey DP
Ion channel expression by white matter glia: the type-1 astrocyte.
Neuron. 1990 Oct;5(4):527-44. PubMed: 1698397PAPER Faideau M, Kim J, Cormier K, Gilmore R, Welch M, Auregan G, Dufour N, Guillermier M, Brouillet E, Hantraye P, Déglon N, Ferrante RJ, Bonvento G
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.
Hum Mol Genet. 2010 Aug 1;19(15):3053-67. Epub 2010 May 21 PubMed: 20494921Coenzyme Q10 Strikes Out in Phase 3 for Parkinson’s
RESEARCH NEWS 2014-03-31 Research News Coenzyme Q10 treatment does not slow the progression of Parkinson’s disease (PD). This was the disappointing conclusion of a Phase 3 clinical trial designed to test the disease-modifying potential of the drug. CoQ10 is an antioxidant that su
PAPER Yang L, Zhao K, Calingasan NY, Luo G, Szeto HH, Beal MF
Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.
Antioxid Redox Signal. 2009 Sep;11(9):2095-104. PubMed: 19203217Alzheimer's Disease- From Fundamental Insights to Light at the End of the Translational Tunnel / Parkinson’s Disease: Genetics, Mechanisms and Therapeutics
CONFERENCE 2014-03-02 00:00:00-2014-03-07 00:00:00 Keystone Resort, Keystone, Colorado, U.S.A. 02 March 2014 to 07 March 2014 Alzheimer’s disease (AD), Parkinson’s disease (PD) and related neurodegenerative disorders are becoming increasingly more prevalent in the United States and globally due to the lon
Donna M. Wilcock on Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.
COMMENT These findings are very significant and add to the growing body of literature suggesting that astrocytes play a pivotal role in neurodegenerative disorders, as well as simply being bystanders in the disease process. It is too early to suggest that this co
Michael Farmer
MRCLondon, United Kingdom
PAPER Sachs-Ericsson N, Moxley JH, Corsentino E, Rushing NC, Sheffler J, Selby EA, Gotlib I, Steffens DC
Melancholia in later life: late and early onset differences in presentation, course, and dementia risk.
Int J Geriatr Psychiatry. 2014 Feb 12; PubMed: 24677247PAPER van der Linde RM, Dening T, Matthews FE, Brayne C
Grouping of behavioural and psychological symptoms of dementia.
Int J Geriatr Psychiatry. 2013 Oct 16; PubMed: 24677112Current Filters
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