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Research Brief: New BACE Inhibitor Joins the Fold

RESEARCH NEWS 2014-10-31 Research News Vitae Pharmaceuticals' BACE inhibitor, VTP-37948, lowered cerebrospinal fluid Aβ by up to 80 percent in healthy volunteers, according to topline data from a Phase 1 clinical trial. A second Phase 1 trial that used a single ascending ...

In ALS, Astrocytes Use Ion Pump to Blast Motor Neurons

RESEARCH NEWS 2014-10-31 Research News In some familial forms of amyotrophic lateral sclerosis, mutant astrocytes damage neighboring neurons. Researchers do not know how. In the October 26 Nature Neuroscience online, scientists report a vital clue: Those mutant astrocytes are ...

Does Novel Tau Protease Promote Pathology?

RESEARCH NEWS 2014-10-31 Research News Neurofibrillary tangles, which contain a mixture of hyperphosphorylated tau fragments, are a hallmark of tauopathies such as Alzheimer's and frontotemporal dementia. Scientists debate which of many tau proteases contribute most to ...

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