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Colin Masters on PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial

COMMENT The IMAGINE study conducted by Prana Biotechnology was a small (n=42) exploratory trial supported by a grant from the Alzheimer’s Drug Discovery Foundation to see if the novel 8-OH quinoline (PBT2) would have an effect on Aβ-amyloid burden as reported by

Susan Landau on PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial

COMMENT Our group has been working on longitudinal amyloid PET measurements recently, and there are a number of methodological challenges. Measuring longitudinal amyloid PET is new territory, and there is not yet a clear answer about the best way to do it. The fi

Schneider Lon on PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial

COMMENT The big picture here is that Prana’s only prior Phase 2 trial with PBT2 — completed in 2007 with 78 mild AD patients treated for 12 weeks — showed lower CSF Aβ42 and nominally significant effects on verbal fluency and working memory. A reasonable developm

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