PAPER Egert S, Piechura H, Hambruch N, Feigel M, Blöchl A
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Leucine-rich repeat kinase 2 (LRRK2)
ALZPEDIA Missense mutations in LRRK2 were first identified as a cause of Parkinson’s disease (PD) in 2004. Subsequent studies showed that these mutations account for up to 10 percent of familial cases, with even higher prevalence in Ashkenazi Jewish and North Afri
PAPER Sloan M, Alegre-Abarrategui J, Wade-Martins R
Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.
Biochem Soc Trans. 2012 Oct;40(5):1080-5. PubMed: 22988869PAPER Dzamko N, Halliday GM
An emerging role for LRRK2 in the immune system.
Biochem Soc Trans. 2012 Oct;40(5):1134-9. PubMed: 22988878PAPER Tsika E, Moore DJ
Contribution of GTPase activity to LRRK2-associated Parkinson disease.
Small GTPases. 2013 Jul-Sep;4(3):164-70. Epub 2013 Jun 10 PubMed: 24025585PAPER Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S
Necroptosis drives motor neuron death in models of both sporadic and familial ALS.
Neuron. 2014 Mar 5;81(5):1001-8. Epub 2014 Feb 6 PubMed: 24508385PAPER Jovičić A, Gitler AD
TDP-43 in ALS: stay on target…almost there.
Neuron. 2014 Feb 5;81(3):463-5. PubMed: 24507183PAPER Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
Neuron. 2014 Feb 5;81(3):536-43. PubMed: 24507191PAPER Hoang QQ
Pathway for Parkinson disease.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2402-3. Epub 2014 Feb 7 PubMed: 24510898PAPER Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA, International Parkinson’s Disease Genomics Consortium, North American Brain Expression Consortium, Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. Epub 2014 Feb 7 PubMed: 24510904Zhaoqing Ding
Johnson & Johnson
Death in a Dish: Astrocytes from ALS Patients Flick Necroptosis Switch in Motor Neurons
RESEARCH NEWS 2014-02-10 Research News For astrocytes from patients with sporadic amyotrophic lateral sclerosis (sALS), killing motor neurons seems just like riding a bike—once they know how to do it, they appear to never forget. Researchers led by Serge Przedborski at Columbia U
Jackson Leavitt
PAPER Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, Lenormand P, Rousselle JC, Namane A, England P, Lorenzo HK, Susin SA
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX.
EMBO J. 2010 May 5;29(9):1585-99. Epub 2010 Apr 1 PubMed: 20360685PAPER Godichaud S, Si-Tayeb K, Augé N, Desmoulière A, Balabaud C, Payrastre B, Nègre-Salvayre A, Rosenbaum J
The grape-derived polyphenol resveratrol differentially affects epidermal and platelet-derived growth factor signaling in human liver myofibroblasts.
Int J Biochem Cell Biol. 2006;38(4):629-37. Epub 2005 Nov 28 PubMed: 16343977Current Filters
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