PAPER Aizenstein, Nebes, Saxton, Price, Mathis, Tsopelas, Ziolko, Snitz, Houck PR, Bi, Cohen, Lopresti, DeKosky, Halligan, Klunk

Amyloid deposition is frequent and often is not associated with significant cognitive impairment in the elderly

Archives of Neurology (in press).

Jessica Goodman

Biogen Idec

David Campbell

Southwest Diagnostic Center for Molecular Imaging
Dallas, United States

Juan Hui

Sandy Lai

XCi

Marg Jennings

Jacques Hugon

University of Paris Diderot
PARIS, France

Gil Block

The Willmatt Group LLC
Haverford

alex thomus

working
hyderabad, India

Hiroki Takeuchi

NHO Minami Kyoto Hospital
Joyo, Japan

Erika Zai

Tangerang

RNA-DNA Pairs: At the Root of C9ORF72 Repeat Damage?

RESEARCH NEWS 2014-03-08 Research News Researchers have uncovered a new explanation for the chaos caused by a hexanucleotide repeat expansion in the C9ORF72 gene, the most common genetic cause of sporadic and familial amyotrophic lateral sclerosis and frontotemporal dementia. In

PAPER Bochman ML, Paeschke K, Zakian VA

DNA secondary structures: stability and function of G-quadruplex structures.

Nat Rev Genet. 2012 Nov;13(11):770-80. Epub 2012 Oct 3 PubMed: 23032257

David Holtzman on Neuronal activity regulates extracellular tau in vivo.

COMMENT We agree with the comment by Irene Griswold-Prenner that given the results by both Pooler et al. and Yamada et al., it will be very interesting to determine whether secreted forms of tau are linked in any way to hyperexcitability and possibly seizures. 0

Aβ: Served Up by More Than Just Excitatory Neurons

RESEARCH NEWS 2014-03-08 Research News It is commonly thought that neurons, especially excitatory ones, produce most of the Aβ in the brain. A paper in the March 5 Journal of Neuroscience suggests other cell types contribute as well. Scientists led by Sangram Sisodia, University