PAPER Dauer WT, Guo M24725399
University of Utah
RESEARCH NEWS 2014-04-15 Research News A decade after the discovery that mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, researchers are still trying to get a handle on how the giant, 51-exon, multi-catalytic protein exerts its pathogenic power. Now,
University Magna Graecia of CatanzaroCatanzaro, Italy
Bingwei Lu on Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease.
COMMENT The most important finding of the paper, in my view, is the biochemical and genetic demonstration that aberrant regulation of protein synthesis contributes to LRRK2-G2019S pathogenesis. This resonates with earlier studies in Drosophila Parkinson's di
Gaia Skibinski on Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson's Disease.
COMMENT The paper highlights the ribosomal protein S15 as a novel pathogenic LRRK2 substrate. Their hypothesis is supported by both in vivo and in vitro models of LRRK2 pathogenesis. The hypothesis that G2019S LRRK2 toxicity leads to bulk increase in protein synt
PAPER Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, Stankowski J, Kim MS, Zhong J, Kumar M, Andrabi SA, Xiong Y, Dickson DW, Wszolek ZK, Pandey A, Dawson TM, Dawson VL24725412
PPDPunta Gorda, United States
CONFERENCE 2014-08-02 00:00:00-2014-08-03 00:00:00 Waterville Valley Resort, Waterville Valley, New Hampshire, U.S.A. 02 – 03 August 2014 The Synaptic Transmission seminar offers a unique opportunity to present and exchange new data and cutting edge ideas. The primary aims are to: (1) provide a
CONFERENCE 2014-08-03 00:00:00-2014-08-08 00:00:00 Waterville Valley Resort, Waterville Valley, New Hampshire, U.S.A. 03 – 08 August 2014 Synapses are the main sites of communication in the nervous system and are also critically involved in several major brain diseases. The conference aims to in
CONFERENCE 2014-07-19 00:00:00-2014-07-20 00:00:00 Sunday River Resort, Newry, Maine, U.S.A. 19 – 20 July 2014 The Gordon Research Seminar on Neurobiology of Cognition is a unique forum for graduate students, postdocs, and other scientists with comparable levels of experience and education to pr
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