PAPER Matsuoka Y, Li X, Bennett V10950304
Christian Lobsiger on An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.
COMMENT This study by Gallardo et al. from the Bonni lab is an impressive work that reveals essential new insights into the enigmatic glial-derived non-cell autonomous toxicity of ALS. The paper starts with a classic scientific approach—simple and unspectacular ...
Albrecht Clement on An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.
COMMENT The study by Gallardo and colleagues is certainly a significant and important contribution to the field. The authors provide compelling evidence, by cell culture and genetic studies as well as by a pharmacological treatment, that a new player in the field ...
Richard Bedlack on An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.
COMMENT To my knowledge, this is the first time this particular mechanism has been manipulated in any model of ALS. While this preclinical data is very interesting, it is not clear that it means anything for people with ALS yet. Many other drugs prolong survival ...
Erik Portelius on Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.
COMMENT This is a very comprehensive study where the authors have used various techniques and models to show that a specific endopeptidase (AEP) degrades tau. It has been known for some years that tau is degraded and fragments of tau have previously been detected ...
RESEARCH NEWS 2014-10-31 Research News Neurofibrillary tangles, which contain a mixture of hyperphosphorylated tau fragments, are a hallmark of tauopathies such as Alzheimer's and frontotemporal dementia. Scientists debate which of many tau proteases contribute most to ...
PAPER Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu ZJ
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.Cell Res. 2014 Mar;24(3):344-58. Epub 2014 Jan 10 PubMed: 24407422
PAPER Ma L, Shen YQ, Khatri HP, Schachner M
The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.PLoS One. 2014;9(4):e95098. Epub 2014 Apr 18 PubMed: 24747977
PAPER Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice.J Biol Chem. 2003 Aug 29;278(35):33194-9. Epub 2003 May 29 PubMed: 12775715
PAPER Madan JR, Argade NS, Dua K25354347
John Cirrito on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
COMMENT This study by Lawrence et al. on the activity of the N-terminal fragment of Aβ raises some important questions regarding the physiological roles of APP cleavage products. As APP is cleaved, it makes sense that the products could serve as activity ...
Erik Portelius on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
COMMENT From when we first discovered that the β/α generated fragment Aβ1-15 increased in response to γ-secretase inhibitor (GSI) treatment, we have wondered whether inducing the α-secretase pathway is “good or bad.” Lawrence and colleges clearly show that ...
Stanford University School of MedicineStanford, United States
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