PAPER Zhou R, Zhou H, Rui L, Xu J
SEARCH RESULTS
330029 RESULTS
PAPER Edwards SR, Hamlin AS, Marks N, Coulson EJ, Smith MT
Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease.
Clin Exp Pharmacol Physiol. 2014 Oct;41(10):798-806. PubMed: 25115283PAPER Furumiya J, Hashimoto Y
A Descriptive Study of Elderly Patients With Dementia Who Died Wandering Outdoors in Kochi Prefecture, Japan.
Am J Alzheimers Dis Other Demen. 2014 Aug 12; PubMed: 25115170PAPER Charidimou A, Jäger RH, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Werring DJ
White matter perivascular spaces are related to cortical superficial siderosis in cerebral amyloid angiopathy.
Stroke. 2014 Oct;45(10):2930-5. Epub 2014 Aug 12 PubMed: 25116879PAPER Ekman U, Eriksson J, Forsgren L, Domellöf ME, Elgh E, Lundquist A, Nyberg L
Longitudinal changes in task-evoked brain responses in Parkinson's disease patients with and without mild cognitive impairment.
Front Neurosci. 2014;8:207. Epub 2014 Jul 29 PubMed: 25120418PAPER Xavier AJ, d'Orsi E, de Oliveira CM, Orrell M, Demakakos P, Biddulph JP, Marmot MG
English Longitudinal Study of Aging: can Internet/E-mail use reduce cognitive decline?
J Gerontol A Biol Sci Med Sci. 2014 Sep;69(9):1117-21. PubMed: 25116923PAPER MacDougall EE, Mansbach WE, Clark K, Mace RA
The brief cognitive assessment tool (BCAT): cross-validation in a community dwelling older adult sample.
Int Psychogeriatr. 2014 Aug 13;:1-8. PubMed: 25115580APP Y538H
MUTATIONS APP 27326977 GRCh37/hg19 rs45537238 T C Exon 13 Point, Missense Coding Decreased Aβ42 and Aβ40 in cells, without altering Aβ42/Aβ40 ratio. Neuropathology consistent with AD, but not thought to be attributed to this variant. Y538H Alzheimer's Disease:
PSEN1 L166V
MUTATIONS PSEN1 73653576 GRCh37/hg19 C G Exon 6 Point, Missense Coding Unknown; predicted damaging in silico by multiple algorithms. SPECT imaging performed four years after symptom onset showed temporoparietal hypoperfusion. Postmortem evaluation revealed neuropat
PSEN1 S230R
MUTATIONS PSEN1 73659493 GRCh37/hg19 T G Exon 7 Point, Missense Coding Unknown, but multiple in silico algorithms predicted a damaging effect. SPECT imaging showed bilateral parietal hypoperfusion, more marked on the left side. Postmortem evaluation revealed neurop
Drug and Biomarker Candidates for C9ORF72 ALS and FTD
RESEARCH NEWS 2014-08-15 Research News In the August 14 Neuron, researchers offer up a possible treatment and a potential biomarker for amyotrophic lateral sclerosis and frontotemporal dementia caused by mutations in the C9ORF72 gene. Leonard Petrucelli at the Mayo Clinic in Jack
PAPER Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, Cudkowicz ME, Boeve BF, Dickson D, Floeter MK, Traynor BJ, Morelli C, Ratti A, Silani V, Rademakers R, Brown RH, Rothstein JD, Boylan KB, Petrucelli L, Disney MD
Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.
Neuron. 2014 Sep 3;83(5):1043-50. Epub 2014 Aug 14 PubMed: 25132468APP P620L
MUTATIONS APP 27284103 GRCh37/hg19 C T Exon 14 Point, Missense Coding Increased Aβ40 and Aβ42 secretion in cells, without significantly altering the Aβ42/Aβ40 ratio in cells. One reported carrier of the variant had autopsy-confirmed AD. P620L Alzheimer's Dise
PSEN2 A237V
MUTATIONS PSEN2 227076673 GRCh37/hg19 rs200670135 C T Exon 8 Point, Missense Coding Unknown; predicted possibly damaging in silico. Neuropathology consistent with AD. A237V Alzheimer's Disease: Uncertain SignificanceAlzheimer's Disease This variant was fo
PSEN1 I168T
MUTATIONS PSEN1 73653583 GRCh37/hg19 T C Exon 6 Point, Missense Coding No significant effect on Aβ40 or Aβ42 secretion in cells; decreased Aβ42 and abrogated Aβ40 production in vitro. Neuropathology consistent with AD. I168T Alzheimer's Disease: Not Classified
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