SEARCH RESULTS

330059 RESULTS

PAPER Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG

CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.

Cell. 2014 Apr 24;157(3):651-63. PubMed: 24766810

APPsw/0; Pdgfrβ+/-

RESEARCH MODELS Summary These mice model a “two-hit” hypothesis of Alzheimer’s disease, specifically elevated Aβ and vascular dysfunction. Aβ production is enhanced courtesy of a human APP transgene bearing the Swedish mutation, while vascular dysfunction is initiated by

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