GRANT Friday, November 28, 2014- 14:00 Alzheimer's Research UK £500,000 23 January 2015 Global Clinical Trials Fund ...
Martin Citron on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT Over the last years a number of studies have addressed potential on-target liabilities of therapeutic BACE1 inhibition. Many of these studies were based on knockout data alone, or addressed developmental myelination. In contrast, the new study by Herms ...
Stefan Lichtenthaler on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT This is an interesting paper, which fits well with earlier findings reported from Phil Wong’s lab in BACE1-deficient mice (Savonenko et al., 2008). After Carmen Birchmeier’s report last year (Cheret et al., 2013), this is now another story demonstrating ...
RESEARCH NEWS 2014-11-28 Research News The goal of BACE1 inhibition is to stop the production of toxic Aβ. However, a new study reports that at very high doses, the inhibitors may harm the very neurons they are meant to protect. Initial findings were presented by senior author ...
PAPER Grey M, Dunning CJ, Gaspar R, Grey C, Brundin P, Sparr E, Linse S25425650
PAPER Walsh KP, Kuhn TB, Bamburg JR
Cellular prion protein: a co-receptor mediating neuronal cofilin-actin rod formation induced by β-amyloid and proinflammatory cytokines.Prion. 2014 Sep 9; PubMed: 25426519
PAPER Hughes ML, Lowe DA, Shine HE, Carpenter BD, Balsis S
Using the Alzheimer's Association Web Site to Improve Knowledge of Alzheimer's Disease in Health Care Providers.Am J Alzheimers Dis Other Demen. 2014 Nov 25; PubMed: 25425736
PAPER Osman SE, Tischler V, Schneider J
'Singing for the Brain': A qualitative study exploring the health and well-being benefits of singing for people with dementia and their carers.Dementia (London). 2014 Nov 24; PubMed: 25425445
PAPER Yasuno F, Kazui H, Morita N, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Matsuoka K, Kosaka J, Kudo T, Iida H, Kishimoto T
Low amyloid-β deposition correlates with high education in cognitively normal older adults: a pilot study.Int J Geriatr Psychiatry. 2014 Nov 26; PubMed: 25425062
PAPER Lin X, Bai G, Lin L, Wu H, Cai J, Ugen KE, Cao C
Vaccination induced changes in pro-inflammatory cytokine levels as an early putative biomarker for cognitive improvement in a transgenic mouse model for Alzheimer disease.Hum Vaccin Immunother. 2014 Jul;10(7):2024-31. PubMed: 25424812
PAPER Zimmer ER, Leuzy A, Gauthier S, Rosa-Neto P25424608
PAPER Yuan TF, Shan C25424433
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