Martin Citron on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT Over the last years a number of studies have addressed potential on-target liabilities of therapeutic BACE1 inhibition. Many of these studies were based on knockout data alone, or addressed developmental myelination. In contrast, the new study by Herms ...
Stefan Lichtenthaler on Pharmacological Inhibition of Beta Site Amyloid Precursor Protein Cleaving Enzyme 1 Can Impair Synaptic Plasticity and Sepcific Cognitive Functions
COMMENT This is an interesting paper, which fits well with earlier findings reported from Phil Wong’s lab in BACE1-deficient mice (Savonenko et al., 2008). After Carmen Birchmeier’s report last year (Cheret et al., 2013), this is now another story demonstrating ...
RESEARCH NEWS 2014-11-28 Research News The goal of BACE1 inhibition is to stop the production of toxic Aβ. However, a new study reports that at very high doses, the inhibitors may harm the very neurons they are meant to protect. Initial findings were presented by senior author ...
Fordham UniversityNew York, United States
PAPER Filser S, Ovsepian SV, Masana M, Blazquez-Llorca L, Elvang AB, Volbracht C, Muller MB, Jung CKE, Herms J
Christchurch, United Kingdom
Michael van Es on Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.
COMMENT I am not surprised by these findings. When we initially proposed that some familial ALS cases might be oligogenic, this view was met with considerable skepticism. Since then, multiple papers have come out looking at multiple genes in a cohort of patients. ...
RESEARCH NEWS 2014-11-27 Research News The genomes of people with amyotrophic lateral sclerosis, even so-called sporadic cases, are often blemished by rare variants that may increase risk for the disease. Some unlucky folk tote two or even three of these potential risk alleles, ...
PAPER Manolio TA23835440
Marc Aurel Busche on Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease.
COMMENT In this elegant study, Šišková et al. used a combination of approaches to examine the morphological and electrophysiological properties of pyramidal neurons in the CA1 region of the hippocampus in a transgenic mouse model of Alzheimer's disease ...
PAPER Lisman JE9004418
PAPER Grienberger C, Chen X, Konnerth A24560703
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