PAPER Macdonald IR, Rockwood K, Martin E, Darvesh S
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PAPER Pavlovic AM, Pekmezovic T, Tomic G, Trajkovic JZ, Sternic N
Baseline predictors of cognitive decline in patients with cerebral small vessel disease.
J Alzheimers Dis. 2014;42 Suppl 3:S37-43. PubMed: 24898641PAPER Eichler T, Thyrian JR, Hertel J, Köhler L, Wucherer D, Dreier A, Michalowsky B, Teipel S, Hoffmann W
Rates of formal diagnosis in people screened positive for dementia in primary care: results of the DelpHi-Trial.
J Alzheimers Dis. 2014;42(2):451-8. PubMed: 24898640PAPER Kim E, Jung YS, Kim H, Kim JS, Park M, Jeong J, Lee SK, Yoon HG, Hwang GS, Namkoong K
Metabolomic signatures in peripheral blood associated with Alzheimer's disease amyloid-β-induced neuroinflammation.
J Alzheimers Dis. 2014;42(2):421-33. PubMed: 24898638PAPER Olazarán J, González B, Osa-Ruiz E, Felipe-Ruiz S, Boyano I, Fontani V, Castagna A, Mendoza C, Zea MA, Frades B, Rinaldi S, Martínez-Martín P
Motor effects of radio electric asymmetric conveyer in Alzheimer's disease: results from a cross-over trial.
J Alzheimers Dis. 2014;42(1):325-32. PubMed: 24898637PAPER Moon M, Choi JG, Kim SY, Oh MS
Bombycis excrementum reduces amyloid-β oligomer-induced memory impairments, neurodegeneration, and neuroinflammation in mice.
J Alzheimers Dis. 2014;41(2):599-613. PubMed: 24898636PAPER Roy K, Pepin LC, Philiossaint M, Lorius N, Becker JA, Locascio JJ, Rentz DM, Sperling RA, Johnson KA, Marshall GA
Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum.
J Alzheimers Dis. 2014;42(1):291-300. PubMed: 24898635PAPER Barbisin M, Vanni S, Schmädicke AC, Montag J, Motzkus D, Opitz L, Salinas-Riester G, Legname G
Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.
BMC Genomics. 2014 Jun 5;15:434. PubMed: 24898206PAPER Zwan MD, Ossenkoppele R, Tolboom N, Beunders AJ, Kloet RW, Adriaanse SM, Boellaard R, Windhorst AD, Raijmakers P, Adams H, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BN
Comparison of Simplified Parametric Methods for Visual Interpretation of 11C-Pittsburgh Compound-B PET Images.
J Nucl Med. 2014 Jun 4;55(8):1305-1307. PubMed: 24898026PAPER Rosse G
Dihydrooxazines As Inhibitors of BACE-1 or BACE-2.
ACS Med Chem Lett. 2013 May 9;4(5):433-4. Epub 2013 Mar 19 PubMed: 24900690PAPER Cukierman-Yaffe T, Bosch J, Diaz R, Dyal L, Hancu N, Hildebrandt P, Lanas F, Lewis BS, Marre M, Yale JF, Yusuf S, Gerstein HC, ORIGIN Investigators
Effects of basal insulin glargine and omega-3 fatty acid on cognitive decline and probable cognitive impairment in people with dysglycaemia: a substudy of the ORIGIN trial.
Lancet Diabetes Endocrinol. 2014 Jul;2(7):562-72. Epub 2014 Jun 2 PubMed: 24898834PAPER Whitmer RA
Cognitive impairment in ORIGIN: timing is everything.
Lancet Diabetes Endocrinol. 2014 Jul;2(7):531-2. Epub 2014 Jun 2 PubMed: 24898832PAPER András IE, Toborek M
HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling.
Exp Cell Res. 2014 Apr 15;323(1):66-76. Epub 2014 Jan 31 PubMed: 24491918PAPER Fowler SW, Chiang AC, Savjani RR, Larson ME, Sherman MA, Schuler DR, Cirrito JR, Lesné SE, Jankowsky JL
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.
J Neurosci. 2014 Jun 4;34(23):7871-85. PubMed: 24899710Terrence Town on TREM2 Mystery: Altered Microglia, No Effect on Plaques
COMMENT In this interesting report, David Holtzman’s group has provided the first test of TREM2 heterozygous loss in a mouse model of cerebral amyloidosis (APPPS1-21). Their report is both timely and provocative, given recent GWAS results implicating a single all
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