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Calcium Sensor STIM2 Maintains Synapses, Ebbs in Alzheimer’s
RESEARCH NEWS 2014-04-02 Research News In Alzheimer’s disease, cognitive decline correlates most closely with the loss of synapses, but exactly what makes them vanish remains a mystery. Now, in the April 2 Neuron, researchers led by Ilya Bezprozvanny at the University of Texas So
PAPER Bourne J, Harris KM
Do thin spines learn to be mushroom spines that remember?
Curr Opin Neurobiol. 2007 Jun;17(3):381-6. Epub 2007 May 10 PubMed: 17498943Bruno Pietro Imbimbo on PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial
COMMENT The community as a whole—independent researchers, colleagues and competitors alike—are eagerly awaiting a successful AD trial, hence there is widespread disappointment about the results of this 52-week study of PBT2 in 42 prodromal AD or mild AD patients.
PAPER Kaye JA, Moore MM, Dame A, Quinn J, Camicioli R, Howieson D, Corbridge E, Care B, Nesbit G, Sexton G
Asynchronous regional brain volume losses in presymptomatic to moderate AD.
J Alzheimers Dis. 2005 Sep;8(1):51-6. PubMed: 16155349Alzforum Editors on Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.
COMMENT Comment posted by the editors on behalf of Xiao-Jiang Li, Distinguished Professor of Human Genetics, Emory University School of Medicine: I read this paper and found it an interesting work. The new finding is that improving glial function can alleviate mo
Alzforum Editors
United States
Lon S. Schneider on PBT2 Takes a Dive in Phase 2 Alzheimer’s Trial
COMMENT The big picture here is that Prana’s only prior Phase 2 trial with PBT2 — completed in 2007 with 78 mild AD patients treated for 12 weeks — showed lower CSF Aβ42 and nominally significant effects on verbal fluency and working memory. A reasonable developm
PAPER Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.
Nat Neurosci. 2014 May;17(5):694-703. Epub 2014 Mar 30 PubMed: 24686787Olga Mitelman
Biogen
Sam Patel
Professional Regulation, IIT BombayMt Prospect, United States
PAPER Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A, Andrisano V, Bottegoni G, Rampa A
Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.
Eur J Med Chem. 2014 May 6;78:157-66. Epub 2014 Mar 16 PubMed: 24681980PAPER Hedera P, Friedman JH
Can fall of blood pressure prevent falls in Parkinson disease?
Neurology. 2014 Apr 29;82(17):1488-9. Epub 2014 Mar 28 PubMed: 24682972PAPER Turturro S, Shen X, Shyam R, Yue BY, Ying H
Effects of mutations and deletions in the human optineurin gene.
Springerplus. 2014;3:99. Epub 2014 Feb 19 PubMed: 24683533PAPER Wang F, Lu Y, Qi F, Su Q, Wang L, You C, Che F, Yu J
Effect of the human SOD1-G93A gene on the Nrf2/ARE signaling pathway in NSC-34 cells.
Mol Med Rep. 2014 Jun;9(6):2453-8. Epub 2014 Mar 28 PubMed: 24682253Current Filters
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