CSIR-NCLPune , India
University of BathBath, United Kingdom
Bond University Gold Coast) Griffith Uni(Gold Coast)Gold Coast, Australia
AmgenBerkeley , United States
Vicksburg, United States
COMMENT Liguori and colleagues report increased orexin in CSF from patients with mild to moderate Alzheimer’s disease (MMSE score <21). In parallel, these patients also had impaired nocturnal sleep compared to controls and patients with mild AD (MMSE score ≥ ...
PAPER Silva A, Andersen ML, De Mello MT, Bittencourt LR, Peruzzo D, Tufik S
Gender and age differences in polysomnography findings and sleep complaints of patients referred to a sleep laboratory.Braz J Med Biol Res. 2008 Dec;41(12):1067-75. PubMed: 19148368
COMMENT This study significantly adds to our understanding about the relationship between sleep, orexin, and AD. The authors measure sleep more robustly than in other published studies with home sleep patterns reported via sleep diaries and an acclimation ...
RESEARCH NEWS 2014-10-17 Research News People with moderate to severe Alzheimer’s disease (AD) may be kept awake by a neurotransmitter that goes bump in the night. According to a study published October 13 in JAMA Neurology, cerebrospinal fluid levels of orexin, a peptide ...
PAPER Liguori C, Romigi A, Nuccetelli M, Zannino S, Sancesario G, Martorana A, Albanese M, Mercuri NB, Izzi F, Bernardini S, Nitti A, Sancesario GM, Sica F, Marciani MG, Placidi F25322206
RESEARCH NEWS 2014-10-17 Research News Mouse models of Alzheimer’s fail to capture many aspects of human disease. Might monkeys do a better job? In the October 8 Journal of Neuroscience, researchers led by Fernanda De Felice at the Federal University of Rio de Janeiro, make a ...
PAPER Podlisny MB, Tolan DR, Selkoe DJ
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.Am J Pathol. 1991 Jun;138(6):1423-35. PubMed: 1905108
University of North Carolina at Chapel Hill
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