PAPER Wajman JR, Oliveira FF, Schultz RR, Marin Sd, Bertolucci PH

Educational bias in the assessment of severe dementia: Brazilian cutoffs for severe Mini-Mental State Examination.

Arq Neuropsiquiatr. 2014 Apr;72(4):273-7. PubMed: 24760090

PAPER Walsh KP, Minamide LS, Kane SJ, Shaw AE, Brown DR, Pulford B, Zabel MD, Lambeth JD, Kuhn TB, Bamburg JR

Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons.

PLoS One. 2014;9(4):e95995. Epub 2014 Apr 23 PubMed: 24760020

PAPER Lee SH, Kim Y, Kim HY, Kim YH, Kim MS, Kong JY, Lee MH, Kim DJ, Ahn YG

Aminostyrylbenzofuran directly reduces oligomeric amyloid-β and reverses cognitive deficits in Alzheimer transgenic mice.

PLoS One. 2014;9(4):e95733. Epub 2014 Apr 23 PubMed: 24760018

PAPER Yuzwa SA, Vocadlo DJ

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

Chem Soc Rev. 2014 Oct 7;43(19):6839-58. Epub 2014 Apr 24 PubMed: 24759912

PAPER Shin S, Kim JH, Cho JH, Kim GS, Choi SA, Lee JH, For the Alzheimer’s Disease Neuroimaging Initiative

Mild Cognitive Impairment Due to Alzheimer Disease is Less Likely Under the Age of 65.

Alzheimer Dis Assoc Disord. 2014 Apr 22; PubMed: 24759547

PAPER Liu L, Zhang K, Tan L, Chen YH, Cao YP

Alterations in Cholesterol and Ganglioside GM1 Content of Lipid Rafts in Platelets From Patients With Alzheimer Disease.

Alzheimer Dis Assoc Disord. 2014 Apr 22; PubMed: 24759545

PAPER Mormont E, Jamart J, Jacques D

Symptoms of Depression and Anxiety After the Disclosure of the Diagnosis of Alzheimer Disease.

J Geriatr Psychiatry Neurol. 2014 Apr 22; PubMed: 24759087

PAPER Zhang J, Zhou X, Yu Q, Yang L, Sun D, Zhou Y, Liu J

Epigallocatechin-3-gallate (EGCG)-stabilized selenium nanoparticles coated with Tet-1 peptide to reduce amyloid-β aggregation and cytotoxicity.

ACS Appl Mater Interfaces. 2014 Jun 11;6(11):8475-87. Epub 2014 May 1 PubMed: 24758520

PAPER Qu J, Zhou Q, Du Y, Zhang W, Bai M, Zhang Z, Xi Y, Li Z, Miao J

Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion.

Br J Pharmacol. 2014 Aug;171(15):3702-15. PubMed: 24758388

PAPER Liu YJ, Fu Y

[Progress of experimental research on treating Alzheimer's disease by acupuncture].

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Mar;34(3):359-61. PubMed: 24758091

PAPER Chung YG, Eum JH, Lee JE, Shim SH, Sepilian V, Hong SW, Lee Y, Treff NR, Choi YH, Kimbrel EA, Dittman RE, Lanza R, Lee DR

Human somatic cell nuclear transfer using adult cells.

Cell Stem Cell. 2014 Jun 5;14(6):777-80. Epub 2014 Apr 17 PubMed: 24746675

Roslyn Stanford

Calwell, Australia

Does Dendritic Tau Promote Plasticity?

RESEARCH NEWS 2014-04-25 Research News In Alzheimer’s brains, the axonal protein tau strays into dendritic spines and stirs up trouble at synapses. Researchers have called this a mislocalization, but a paper in the April 23 Journal of Neuroscience challenges this view, suggesting

Hans Zempel on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

COMMENT This study from the Buisson lab adds more data arguing that tau may contribute to the regulation of synaptic plasticity. It has long been known that tau can bind to f-actin, particularly when phosphorylated at the KXGS-motifs (Mandelkow et al., 2004; Whit

C9ORF72 Repeats Expand into New Disorders—Cause, or Coincidence?

RESEARCH NEWS 2014-04-25 Research News Long repeat sequences in the C9ORF72 gene have cropped up in cases of multiple system atrophy (MSA) and depressive pseudodementia, according to two new case studies. The findings, published in JAMA Neurology on April 14 and 21, respectively,