PAPER Deng Q, Holler CJ, Taylor G, Hudson KF, Watkins W, Gearing M, Ito D, Murray ME, Dickson DW, Seyfried NT, Kukar T

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

J Neurosci. 2014 Jun 4;34(23):7802-13. PubMed: 24899704

Test Battery Picks Up Cognitive Decline in Normal Populations

RESEARCH NEWS 2014-06-06 Research News Researchers conducting Alzheimer’s prevention studies face a dilemma: how to measure effects on cognition in normal populations? With no validated measure available for this purpose, scientists have pioneered new instruments by combining tes

Moira Jenkins

Cork Institute of Technology
Cork, Ireland

PAPER Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M

The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.

Nat Commun. 2014 Jun 4;5:3917. PubMed: 24894631

PAPER Kandalepas PC, Vassar R

The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.

Curr Alzheimer Res. 2014;11(5):441-9. PubMed: 24893886

PAPER Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, Tosatto L, Belluzzi E, Greggio E, Bisaglia M, Capaldi S, Aioanei D, Mammi S, Monaco HL, Samo B, Bubacco L

The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity.

Hum Mol Genet. 2014 Nov 1;23(21):5615-29. Epub 2014 Jun 3 PubMed: 24895406

PAPER Krismer F, Jellinger KA, Scholz SW, Seppi K, Stefanova N, Antonini A, Poewe W, Wenning GK

Multiple system atrophy as emerging template for accelerated drug discovery in α-synucleinopathies.

Parkinsonism Relat Disord. 2014 Aug;20(8):793-9. Epub 2014 May 21 PubMed: 24894118

PAPER Gargiulo-Monachelli GM, Campos-Melo D, Droppelmann CA, Keller BA, Leystra-Lantz C, De Nicola AF, Gonzalez Deniselle MC, Volkening K, Strong MJ

Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord.

Eur J Neurol. 2014 Feb;21(2):273-80.e11. Epub 2013 Nov 7 PubMed: 24894997

PAPER Fawaz MV, Brooks AF, Rodnick ME, Carpenter GM, Shao X, Desmond TJ, Sherman P, Quesada CA, Hockley BG, Kilbourn MR, Albin RL, Frey KA, Scott PJ

High affinity radiopharmaceuticals based upon lansoprazole for PET imaging of aggregated tau in Alzheimer's disease and progressive supranuclear palsy: synthesis, preclinical evaluation, and lead selection.

ACS Chem Neurosci. 2014 Aug 20;5(8):718-30. Epub 2014 Jun 16 PubMed: 24896980

PAPER Allgaier M, Allgaier C

An update on drug treatment options of Alzheimer's disease.

Front Biosci (Landmark Ed). 2014 Jun 1;19:1345-54. PubMed: 24896354

PAPER Chen ST, Siddarth P, Ercoli LM, Merrill DA, Torres-Gil F, Small GW

Modifiable risk factors for Alzheimer disease and subjective memory impairment across age groups.

PLoS One. 2014;9(6):e98630. Epub 2014 Jun 4 PubMed: 24896243

PAPER Zaręba-Kozioł M, Szwajda A, Dadlez M, Wysłouch-Cieszyńska A, Lalowski M

Global analysis of S-nitrosylation sites in the wild type (APP) transgenic mouse brain-clues for synaptic pathology.

Mol Cell Proteomics. 2014 Sep;13(9):2288-305. Epub 2014 Jun 3 PubMed: 24895380

PAPER Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A

Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.

J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1339-52. Epub 2014 Jun 3 PubMed: 24895269

PAPER Boyd RE, Valenzano KJ

Correction of lysosomal dysfunction as a therapeutic strategy for neurodegenerative diseases.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3001-5. Epub 2014 May 14 PubMed: 24894562

PAPER Lemos R, Simões MR, Santiago B, Santana I

The free and cued selective reminding test: Validation for mild cognitive impairment and Alzheimer's disease.

J Neuropsychol. 2014 Jun 3; PubMed: 24894485