SEARCH RESULTS
329939 RESULTS
Jacques Hugon
University of Paris DiderotPARIS, France
Gil Block
The Willmatt Group LLCHaverford
alex thomus
workinghyderabad, India
Hiroki Takeuchi
NHO Minami Kyoto HospitalJoyo, Japan
Erika Zai
Tangerang
RNA-DNA Pairs: At the Root of C9ORF72 Repeat Damage?
RESEARCH NEWS 2014-03-08 Research News Researchers have uncovered a new explanation for the chaos caused by a hexanucleotide repeat expansion in the C9ORF72 gene, the most common genetic cause of sporadic and familial amyotrophic lateral sclerosis and frontotemporal dementia. In
PAPER Bochman ML, Paeschke K, Zakian VA
DNA secondary structures: stability and function of G-quadruplex structures.
Nat Rev Genet. 2012 Nov;13(11):770-80. Epub 2012 Oct 3 PubMed: 23032257David Holtzman on Neuronal activity regulates extracellular tau in vivo.
COMMENT We agree with the comment by Irene Griswold-Prenner that given the results by both Pooler et al. and Yamada et al., it will be very interesting to determine whether secreted forms of tau are linked in any way to hyperexcitability and possibly seizures. 0
Aβ: Served Up by More Than Just Excitatory Neurons
RESEARCH NEWS 2014-03-08 Research News It is commonly thought that neurons, especially excitatory ones, produce most of the Aβ in the brain. A paper in the March 5 Journal of Neuroscience suggests other cell types contribute as well. Scientists led by Sangram Sisodia, University
Irene Griswold-Prenner on Neuronal activity regulates extracellular tau in vivo.
COMMENT The past few years of tau research have provided strong evidence that endogenous tau secretion does occur in the absence of neuronal lysis. One of the next steps is to understand how a cytosolic protein such as tau is secreted. We and others in the field
Benedikt Kretner
TU DresdenDresden, Germany
DIAN Longitudinal Data Surprises With Late Drop in Tau
RESEARCH NEWS 2014-03-08 Research News Current models of biomarker change in Alzheimer’s disease have been based mostly on cross-sectional data. In the March 5 Science Translational Medicine, researchers led by Anne Fagan at Washington University in St. Louis provide the first gl
PAPER Hook G, Yu J, Toneff T, Kindy M, Hook V
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
J Alzheimers Dis. 2014;41(1):129-49. PubMed: 24595198PAPER Gath J, Bousset L, Habenstein B, Melki R, Böckmann A, Meier BH
Unlike twins: an NMR comparison of two α-synuclein polymorphs featuring different toxicity.
PLoS One. 2014;9(3):e90659. Epub 2014 Mar 5 PubMed: 24599158Current Filters
No filters selected