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RNA-DNA Pairs: At the Root of C9ORF72 Repeat Damage?

RESEARCH NEWS 2014-03-08 Research News Researchers have uncovered a new explanation for the chaos caused by a hexanucleotide repeat expansion in the C9ORF72 gene, the most common genetic cause of sporadic and familial amyotrophic lateral sclerosis and frontotemporal dementia. In

Aβ: Served Up by More Than Just Excitatory Neurons

RESEARCH NEWS 2014-03-08 Research News It is commonly thought that neurons, especially excitatory ones, produce most of the Aβ in the brain. A paper in the March 5 Journal of Neuroscience suggests other cell types contribute as well. Scientists led by Sangram Sisodia, University

DIAN Longitudinal Data Surprises With Late Drop in Tau

RESEARCH NEWS 2014-03-08 Research News Current models of biomarker change in Alzheimer’s disease have been based mostly on cross-sectional data. In the March 5 Science Translational Medicine, researchers led by Anne Fagan at Washington University in St. Louis provide the first gl

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