Jerry Nielson

Allergan
Scotch Plains, United States

Cognitive Deficits Arise From Network, Not Regional, Dysfunction

RESEARCH NEWS 2014-03-21 Research News Growing evidence suggests that a breakdown in the brain’s communications networks underlies the clinical symptoms of dementia. In the March 19 Neuron, researchers led by Gaël Chételat at Inserm-EPHE-Université of Caen, France, and first auth

PAPER Ranganath C, Ritchey M

Two cortical systems for memory-guided behaviour.

Nat Rev Neurosci. 2012 Oct;13(10):713-26. PubMed: 22992647

Test Uses 'Seeding' to Detect Aβ Oligomers in Cerebrospinal Fluid

RESEARCH NEWS 2014-03-21 Research News Small clusters of misfolded Aβ, called oligomers, recruit normal Aβ peptides to contort and clump up in a process called “seeding.” Some scientists hypothesize that these oligomers are the most toxic Aβ species in Alzheimer’s disease and cou

PAPER Randall B, Gerry G, Rance F

Dicyclomine in the sudden infant death syndrome (SIDS)--a cause of death or an incidental finding?

J Forensic Sci. 1986 Oct;31(4):1470-4. PubMed: 3783112

PAPER Crick FH

The Packing of α-Helices- Simple Coiled-Coils

Acta Crystallogr. 1953;6:689-697.

PAPER Schenk D, Carrillo MC, Trojanowski JQ

Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.

Alzheimers Dement. 2006 Oct;2(4):275-81. PubMed: 19595899

sumit sarkar

National Center for Toxicological Research
Jefferson, United States

Irene Knuesel on No REST for Weary Neurons: Protective Factor Stems Cognitive Decline

COMMENT A sizable proportion of elderly individuals with substantial AD pathology does not appear to progress to dementia, indicating that specific neuroprotective mechanisms must exist to evade progressive cognitive decline. The elegant and comprehensive study b

Maiko Uemura

Kyoto University

PAPER Li JG, Chu J, Barrero C, Merali S, Praticò D

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.

Ann Neurol. 2014 Jun;75(6):851-63. Epub 2014 May 28 PubMed: 24644038

PAPER Shanley C

Promoting advance care planning to reduce the impact of dementia: a new web resource from Alzheimer's australia.

BMJ Support Palliat Care. 2013 Jun;3(2) PubMed: 24644606

PAPER Argyri L, Dafnis I, Theodossiou TA, Gantz D, Stratikos E, Chroni A

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

J Biol Chem. 2014 May 2;289(18):12931-45. Epub 2014 Mar 18 PubMed: 24644280

PAPER Schwartz A

What's next for Alzheimer treatment?: while Aβ isn't out of the picture yet, several other therapeutic routes are being explored.

Ann Neurol. 2013 Apr;73(4):A7-9. PubMed: 24643982

PAPER Liu B, Zhu Y, Zhou J, Wei Y, Long C, Chen M, Ling Y, Ge J, Zhuo Y

Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells.

Cell Stress Chaperones. 2014 Mar 19; PubMed: 24643796