RESEARCH MODELS Summary The Tg4-42 model was engineered to produce the peptide Aβ 4-42, one of a variety of N-terminally truncated Aβ species identified in the AD brain. The Aβ 4-42 peptide, which begins with a phenylalanine at position 4, may be a particularly abundant
RESEARCH MODELS Summary The TBA42 model was designed to produce and secrete an N-terminally truncated Aβ peptide. TBA42, which stands for truncated beta-amyloid 42, specifically encodes an Aβ 3–42 peptide with a glutamine substituted for the naturally occurring glutamate
University of California Santa BarbaraSanta Barbara, United States
RESEARCH NEWS 2014-04-28 Research News It appears that scientists have finally succeeded in cloning adult human cells, a goal that has tantalized the field since the first successful cloning of an adult mammal, Dolly the sheep, in 1996. Two independent papers report the generatio
University of AmsterdamAmsterdam, Netherlands
Genentech, Inc. South San Francisco, United States
Université de Grenoble 1Montbonnot , France
PAPER Liu P, Niu Y, Wang C, Sun Q, Zhai Y, Yu J, Sun J, Xu F, Yan G, Huang W, Liang L, Xu P
Eur J Med Chem. 2014 May 22;79:413-21. Epub 2014 Apr 12 PubMed: 24763262