PAPER Kamp JA, Moursel LG, Haan J, Terwindt GM, Lesnik Oberstein SA, van Duinen SG, van Roon-Mom WM
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PAPER Klupp E, Förster S, Grimmer T, Tahmasian M, Yakushev I, Sorg C, Yousefi BH, Drzezga A
In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions.
Brain Connect. 2014 Jun;4(5):371-83. PubMed: 24870443PAPER Nair S, Traini M, Dawes IW, Perrone GG
Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.
Mol Biol Cell. 2014 Aug 1;25(15):2235-49. Epub 2014 May 28 PubMed: 24870034PAPER Funk KE, Thomas SN, Schafer KN, Cooper GL, Liao Z, Clark DJ, Yang AJ, Kuret J
Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.
Biochem J. 2014 Aug 15;462(1):77-88. PubMed: 24869773PAPER Liu H, Wang J, Tabira T
Juzen-Taiho-to, an herbal medicine, promotes the differentiation of transplanted bone marrow cells into microglia in the mouse brain injected with fibrillar amyloid β.
Tohoku J Exp Med. 2014;233(2):113-22. PubMed: 24869594PAPER Ogasawara J, Ito T, Wakame K, Kitadate K, Sakurai T, Sato S, Ishibashi Y, Izawa T, Takahashi K, Ishida H, Takabatake I, Kizaki T, Ohno H
ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells.
Nat Prod Commun. 2014 Apr;9(4):561-4. PubMed: 24868884PAPER Koay YH, Basiri A, Murugaiyah V, Chan KL
Isocorilagin, a cholinesterase inhibitor from Phyllanthus niruri.
Nat Prod Commun. 2014 Apr;9(4):515-7. PubMed: 24868872PAPER Cuong TD, Hung TM, Han HY, Roh HS, Seok JH, Lee JK, Jeong JY, Choi JS, Kim JA, Min BS
Potent acetylcholinesterase inhibitory compounds from Myristica fragrans.
Nat Prod Commun. 2014 Apr;9(4):499-502. PubMed: 24868867PAPER Kim HJ, Lee JE, Shin SJ, Sohn YH, Lee PH
Analysis of the substantia innominata volume in patients with Parkinson's disease with dementia, dementia with lewy bodies, and Alzheimer's disease.
J Mov Disord. 2011 Oct;4(2):68-72. Epub 2011 Oct 30 PubMed: 24868398PAPER Shin HW, Sohn YH
Hyperhomocysteinemia in patients with Parkinson's disease and relationship to vitamin B level.
J Mov Disord. 2009 May;2(1):33-6. Epub 2009 Apr 30 PubMed: 24868350PAPER Jang EH, Lee JK, Jang HJ, Kim MJ, Chung SJ
A case of multiple system atrophy-cerebellar type preceded by dementia.
J Mov Disord. 2012 Oct;5(2):48-52. Epub 2012 Oct 30 PubMed: 24868414PAPER Chung EJ, Kim SJ
Levodopa-induced facial dystonia in a case of progressive supranuclear palsy.
J Mov Disord. 2012 May;5(1):28-32. Epub 2012 May 30 PubMed: 24868411PAPER Hong HJ, Song SK, Lee PH, Sohn YH, Lee JE
Cognitive impairments in multiple system atrophy of the cerebellar type.
J Mov Disord. 2011 May;4(1):41-5. Epub 2011 Apr 30 PubMed: 24868391Synaptic Metropolis—Microscopic Census Documents 300,000 Protein Inhabitants
RESEARCH NEWS 2014-05-30 Research News Wielding a combination of imaging and quantification techniques, researchers have generated the most detailed three-dimensional map of the synapse to date, showing how approximately 300,000 proteins squeeze into this tiny space. As reported
Sanjay Pimplikar on Has ApoE’s Time Come as a Therapeutic Target?
COMMENT There has been a growing realization that we need to expand AD drug targets beyond amyloid. Therefore, at first glance the news of ApoE as a potential therapeutic target would be welcomed. As other commentators have pointed out, the Holtzman paper present
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