RESEARCH NEWS 2014-10-31 Research News Neurofibrillary tangles, which contain a mixture of hyperphosphorylated tau fragments, are a hallmark of tauopathies such as Alzheimer's and frontotemporal dementia. Scientists debate which of many tau proteases contribute most to ...
PAPER Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu ZJ
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.Cell Res. 2014 Mar;24(3):344-58. Epub 2014 Jan 10 PubMed: 24407422
PAPER Ma L, Shen YQ, Khatri HP, Schachner M
The asparaginyl endopeptidase legumain is essential for functional recovery after spinal cord injury in adult zebrafish.PLoS One. 2014;9(4):e95098. Epub 2014 Apr 18 PubMed: 24747977
PAPER Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice.J Biol Chem. 2003 Aug 29;278(35):33194-9. Epub 2003 May 29 PubMed: 12775715
John Cirrito on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
COMMENT This study by Lawrence et al. on the activity of the N-terminal fragment of Aβ raises some important questions regarding the physiological roles of APP cleavage products. As APP is cleaved, it makes sense that the products could serve as activity ...
Erik Portelius on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
COMMENT From when we first discovered that the β/α generated fragment Aβ1-15 increased in response to γ-secretase inhibitor (GSI) treatment, we have wondered whether inducing the α-secretase pathway is “good or bad.” Lawrence and colleges clearly show that ...
Stanford University School of MedicineStanford, United States
Laboratory of Medical Physics, Medical School, Aristotle University of ThessalonikiThessaloniki
Pune , India
ANTIBODY monoclonal 1D3 manufacturer Ovalbumin-conjugated linear peptide corresponding to human TDP-43 phosphorylated at serine 409 and 410. Purified in buffer containing 0.1 M Tris glycine with 0.05% sodium azide This antibody recognizes human TDP-43 ...
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