PAPER Klingelhoefer L, Sokolov E, Chaudhuri KR
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PAPER Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Nature. 2014 May 1;509(7498):105-9. Epub 2014 Mar 30 PubMed: 24695223PAPER M B, E L, C K, R MN, S PA, J R, K SS
Embryonic stem cell-derived neurons as a novel cellular model system to study neurodegenerative and neuroregenerative processes in vitro.
J Stem Cells Regen Med. 2007;2(1):62-3. Epub 2007 May 16 PubMed: 24692907PAPER Spalletta G, Robinson RG, Cravello L, Pontieri FE, Pierantozzi M, Stefani A, Long JD, Caltagirone C, Assogna F
The early course of affective and cognitive symptoms in de novo patients with Parkinson's disease.
J Neurol. 2014 Apr 3; PubMed: 24695996PAPER Ray S, Bender S, Kang S, Lin R, Glicksman MA, Liu M
The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.
J Biol Chem. 2014 May 9;289(19):13042-53. Epub 2014 Apr 2 PubMed: 24695735PAPER Alonso-Navarro H, Jimenez-Jimenez FJ, Garcia-Martin E, Agundez JA
Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Curr Drug Metab. 2014 Feb;15(2):129-81. PubMed: 24694231PAPER Ohta E, Obata F
[Pathogenesis of Parkinson's disease through LRRK2 mutation].
Seikagaku. 2014 Feb;86(1):92-7. PubMed: 24693706PAPER Alberts N, Groen K, Klein L, Konieczny MJ, Koopman M
Dorsal root ganglion neurons carrying a P301S Tau mutation: a valid in vitro model for screening drugs against tauopathies?
J Neurosci. 2014 Apr 2;34(14):4757-9. PubMed: 24695695A High-Resolution Wiring Diagram of the Mammalian Brain
RESEARCH NEWS 2014-04-04 Research News Researchers have traced the most comprehensive wiring diagram of the mammalian brain so far. The mouse brain “connectome,” charted by a large team of scientists led by Hongkui Zeng at the Allen Institute for Brain Science in Seattle, tracks
PAPER Oh SW, Harris JA, Ng L, Winslow B, Cain N, Mihalas S, Wang Q, Lau C, Kuan L, Henry AM, Mortrud MT, Ouellette B, Nguyen TN, Sorensen SA, Slaughterbeck CR, Wakeman W, Li Y, Feng D, Ho A, Nicholas E, Hirokawa KE, Bohn P, Joines KM, Peng H, Hawrylycz MJ, Phillips JW, Hohmann JG, Wohnoutka P, Gerfen CR, Koch C, Bernard A, Dang C, Jones AR, Zeng H
A mesoscale connectome of the mouse brain.
Nature. 2014 Apr 10;508(7495):207-14. Epub 2014 Apr 2 PubMed: 24695228Natalie Marchant on Arterial stiffness and β-amyloid progression in nondemented elderly adults.
COMMENT The study by Hughes and colleagues highlights the utility of longitudinal amyloid imaging and pulse wave velocity (PWD) to measure arterial stiffness. By capitalizing on the relatively consistent age-related upward trajectory of PWD, the authors demonstra
Roxana Carare, Roy Weller on Arterial stiffness and β-amyloid progression in nondemented elderly adults.
COMMENT Our group has demonstrated that interstitial fluid and solutes are cleared from the brain by bulk flow along the basement membranes of capillary and artery walls, analogous to the lymphatics of other organs (1). In aging, fibrils of amyloid accumulate in
Can Arterial Health Predict Amyloid Deposition?
RESEARCH NEWS 2014-04-04 Research News In case you needed it, here’s another incentive to take good care of your cardiovascular system. In the March 31 JAMA Neurology, researchers led by Timothy Hughes at Wake Forest School of Medicine, Winston-Salem, North Carolina, reported tha
PAPER Dudenbostel T, Glasser SP
Effects of antihypertensive drugs on arterial stiffness.
Cardiol Rev. 2012 Sep-Oct;20(5):259-63. PubMed: 22573107PAPER Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL
Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.
Neurology. 2013 Nov 5;81(19):1711-8. Epub 2013 Oct 16 PubMed: 24132374Current Filters
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